The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia
Prophylactic antibiotic usage during delivery is a common practice worldwide, especially in low- to middle-income countries. Guidelines have been published to reduce antibiotic overuse; however, data describing the use of prophylactic antibiotics and clinician adherence to guidelines in low- to midd...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/10/8/1004 |
| _version_ | 1797524817186914304 |
|---|---|
| author | Ariesti Karmila Mohammad Zulkarnain Abarham Martadiansyah Putri Mirani Nuswil Bernolian Joseph C. Gardiner Lixin Zhang |
| author_facet | Ariesti Karmila Mohammad Zulkarnain Abarham Martadiansyah Putri Mirani Nuswil Bernolian Joseph C. Gardiner Lixin Zhang |
| author_sort | Ariesti Karmila |
| collection | DOAJ |
| description | Prophylactic antibiotic usage during delivery is a common practice worldwide, especially in low- to middle-income countries. Guidelines have been published to reduce antibiotic overuse; however, data describing the use of prophylactic antibiotics and clinician adherence to guidelines in low- to middle-income countries remain limited. This study aimed to describe the prevalence of prophylactic antibiotic use, factors associated with its use, and clinician adherence to guidelines. A retrospective review was conducted for all deliveries from 1 January 2016 to 31 December 2018 at a tertiary level hospital in Indonesia. The prevalence of prophylactic antibiotic use during delivery was 47.1%. Maternal education level, Ob/Gyn specialist-led delivery, a history of multiple abortions, C-section, premature membrane rupture, and antepartum hemorrhage were independently associated with prophylactic antibiotic use. Clinician adherence to the guidelines was 68.9%. Adherence to guidelines was the lowest in conditions where the patient had only one indication for prophylactic antibiotics (aOR 0.36, 95% CI 0.24–0.54). The findings showed that the prevalence of prophylactic antibiotic use during delivery was moderate to high. Adherence to local guidelines was moderate. Updating the local prescribing guidelines may improve clinician adherence. |
| first_indexed | 2024-03-10T09:02:56Z |
| format | Article |
| id | doaj.art-051cb8222a8e448baf92d51146e67a8c |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T09:02:56Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-051cb8222a8e448baf92d51146e67a8c2023-11-22T06:34:33ZengMDPI AGAntibiotics2079-63822021-08-01108100410.3390/antibiotics10081004The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, IndonesiaAriesti Karmila0Mohammad Zulkarnain1Abarham Martadiansyah2Putri Mirani3Nuswil Bernolian4Joseph C. Gardiner5Lixin Zhang6Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USADepartment of Public Health, Faculty of Medicine, University of Sriwijaya, Palembang 30126, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Sriwijaya, Palembang 30126, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Sriwijaya, Palembang 30126, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Sriwijaya, Palembang 30126, IndonesiaDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USADepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USAProphylactic antibiotic usage during delivery is a common practice worldwide, especially in low- to middle-income countries. Guidelines have been published to reduce antibiotic overuse; however, data describing the use of prophylactic antibiotics and clinician adherence to guidelines in low- to middle-income countries remain limited. This study aimed to describe the prevalence of prophylactic antibiotic use, factors associated with its use, and clinician adherence to guidelines. A retrospective review was conducted for all deliveries from 1 January 2016 to 31 December 2018 at a tertiary level hospital in Indonesia. The prevalence of prophylactic antibiotic use during delivery was 47.1%. Maternal education level, Ob/Gyn specialist-led delivery, a history of multiple abortions, C-section, premature membrane rupture, and antepartum hemorrhage were independently associated with prophylactic antibiotic use. Clinician adherence to the guidelines was 68.9%. Adherence to guidelines was the lowest in conditions where the patient had only one indication for prophylactic antibiotics (aOR 0.36, 95% CI 0.24–0.54). The findings showed that the prevalence of prophylactic antibiotic use during delivery was moderate to high. Adherence to local guidelines was moderate. Updating the local prescribing guidelines may improve clinician adherence.https://www.mdpi.com/2079-6382/10/8/1004prophylactic antibioticsdeliverylow- and middle-income countriesadherence |
| spellingShingle | Ariesti Karmila Mohammad Zulkarnain Abarham Martadiansyah Putri Mirani Nuswil Bernolian Joseph C. Gardiner Lixin Zhang The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia Antibiotics prophylactic antibiotics delivery low- and middle-income countries adherence |
| title | The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia |
| title_full | The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia |
| title_fullStr | The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia |
| title_full_unstemmed | The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia |
| title_short | The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia |
| title_sort | prevalence and factors associated with prophylactic antibiotic use during delivery a hospital based retrospective study in palembang indonesia |
| topic | prophylactic antibiotics delivery low- and middle-income countries adherence |
| url | https://www.mdpi.com/2079-6382/10/8/1004 |
| work_keys_str_mv | AT ariestikarmila theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT mohammadzulkarnain theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT abarhammartadiansyah theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT putrimirani theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT nuswilbernolian theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT josephcgardiner theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT lixinzhang theprevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT ariestikarmila prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT mohammadzulkarnain prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT abarhammartadiansyah prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT putrimirani prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT nuswilbernolian prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT josephcgardiner prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia AT lixinzhang prevalenceandfactorsassociatedwithprophylacticantibioticuseduringdeliveryahospitalbasedretrospectivestudyinpalembangindonesia |