Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1991-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012 |
| _version_ | 1797757934845820928 |
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| author | V. S. N. Rao F. R. C. Almeida A. P. Moraes J. V. Silva S. C. Nascimento M. O. Moraes |
| author_facet | V. S. N. Rao F. R. C. Almeida A. P. Moraes J. V. Silva S. C. Nascimento M. O. Moraes |
| author_sort | V. S. N. Rao |
| collection | DOAJ |
| description | Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%). |
| first_indexed | 2024-03-12T18:21:45Z |
| format | Article |
| id | doaj.art-051d921978544e00a24e6a28594cf947 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:21:45Z |
| publishDate | 1991-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-051d921978544e00a24e6a28594cf9472023-08-02T08:46:24ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601991-01-0186434510.1590/S0074-02761991000600012Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activityV. S. N. RaoF. R. C. AlmeidaA. P. MoraesJ. V. SilvaS. C. NascimentoM. O. MoraesCucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012antitumorWilbrandia verticillatacytotoxicityWalker carcinosarcoma |
| spellingShingle | V. S. N. Rao F. R. C. Almeida A. P. Moraes J. V. Silva S. C. Nascimento M. O. Moraes Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity Memorias do Instituto Oswaldo Cruz antitumor Wilbrandia verticillata cytotoxicity Walker carcinosarcoma |
| title | Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity |
| title_full | Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity |
| title_fullStr | Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity |
| title_full_unstemmed | Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity |
| title_short | Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity |
| title_sort | evaluation of the purified fraction of wilbrandia c f verticillata for antitumour activity |
| topic | antitumor Wilbrandia verticillata cytotoxicity Walker carcinosarcoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012 |
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