Regulatory T cells in skeletal muscle repair and regeneration: recent insights
Abstract Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment deter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-08-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05142-8 |
| _version_ | 1818505486939455488 |
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| author | Jianhui Wu Bowen Ren Daochao Wang Hui Lin |
| author_facet | Jianhui Wu Bowen Ren Daochao Wang Hui Lin |
| author_sort | Jianhui Wu |
| collection | DOAJ |
| description | Abstract Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases. |
| first_indexed | 2024-12-10T21:51:27Z |
| format | Article |
| id | doaj.art-05200a81dd0247fca132ed85615f14fe |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-12-10T21:51:27Z |
| publishDate | 2022-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-05200a81dd0247fca132ed85615f14fe2022-12-22T01:32:11ZengNature Publishing GroupCell Death and Disease2041-48892022-08-0113811110.1038/s41419-022-05142-8Regulatory T cells in skeletal muscle repair and regeneration: recent insightsJianhui Wu0Bowen Ren1Daochao Wang2Hui Lin3Cancer Center, Beijing LuHe Hospital, Capital Medical UniversityJiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang UniversityCancer Center, Beijing LuHe Hospital, Capital Medical UniversityJiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang UniversityAbstract Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases.https://doi.org/10.1038/s41419-022-05142-8 |
| spellingShingle | Jianhui Wu Bowen Ren Daochao Wang Hui Lin Regulatory T cells in skeletal muscle repair and regeneration: recent insights Cell Death and Disease |
| title | Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
| title_full | Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
| title_fullStr | Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
| title_full_unstemmed | Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
| title_short | Regulatory T cells in skeletal muscle repair and regeneration: recent insights |
| title_sort | regulatory t cells in skeletal muscle repair and regeneration recent insights |
| url | https://doi.org/10.1038/s41419-022-05142-8 |
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