Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis
Vitamin D is commonly used to prevent and treat osteoporosis, with studies indicating its potential to reduce fractures, falls, and mortality. However, meta-analyses present inconsistent findings regarding its efficacy, particularly reflecting significant variability in data and outcomes related to...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2024-04-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10449 |
| _version_ | 1797208897126137856 |
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| author | Xiaoyang Tao Wupeng Yang Qinxin Zhang Yongjiang Wang Feng Gao Yuehan Wang Tingxin Zhang Hao Liu Jindong Chen |
| author_facet | Xiaoyang Tao Wupeng Yang Qinxin Zhang Yongjiang Wang Feng Gao Yuehan Wang Tingxin Zhang Hao Liu Jindong Chen |
| author_sort | Xiaoyang Tao |
| collection | DOAJ |
| description |
Vitamin D is commonly used to prevent and treat osteoporosis, with studies indicating its potential to reduce fractures, falls, and mortality. However, meta-analyses present inconsistent findings regarding its efficacy, particularly reflecting significant variability in data and outcomes related to various dosing regimens. In this meta-analysis, we assessed the impact of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality among elderly individuals. We included 14 randomized controlled trials and employed Review Manager 5.4 for statistical analysis. Our findings indicate that intermittent monthly administration of vitamin D3 (over 800 IU per day) significantly raised serum 25(OH)D levels at all timepoints after six months, maintaining levels above 75 nmol/L throughout the year. This regimen showed no increase in all-cause mortality, with a risk ratio (95% CI) of 0.95 (0.87-1.04). Likewise, it did not significantly reduce the risks of falls and fractures, with risk ratios of 1.02 (0.98-1.05) and 0.95 (0.87-1.04) respectively. Although one-year intermittent administration significantly increased the concentration of 25(OH)D in serum, further research is needed to determine if this method would increase the incidence of falls. Therefore, it is not recommended at this stage due to the lack of demonstrated safety in additional relevant RCTs. This study had been registered on PROSPERO (CRD42022363229).
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| first_indexed | 2024-04-24T09:46:06Z |
| format | Article |
| id | doaj.art-05205ef510074336b887b955b3e3bae2 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T09:46:06Z |
| publishDate | 2024-04-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-05205ef510074336b887b955b3e3bae22024-04-14T14:50:01ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2024-04-0110.17305/bb.2024.10449Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysisXiaoyang Tao0Wupeng Yang1Qinxin Zhang2Yongjiang Wang3Feng Gao4Yuehan Wang5Tingxin Zhang6Hao Liu7Jindong Chen8Orthopedics Department, Ordos Central Hospital, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrdos No.1 Middle School, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrthopedics Department, Ordos Central Hospital, Ordos, ChinaOrdos School of Clinical Medicine, Inner Mongolia Medical University, Ordos, China Vitamin D is commonly used to prevent and treat osteoporosis, with studies indicating its potential to reduce fractures, falls, and mortality. However, meta-analyses present inconsistent findings regarding its efficacy, particularly reflecting significant variability in data and outcomes related to various dosing regimens. In this meta-analysis, we assessed the impact of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality among elderly individuals. We included 14 randomized controlled trials and employed Review Manager 5.4 for statistical analysis. Our findings indicate that intermittent monthly administration of vitamin D3 (over 800 IU per day) significantly raised serum 25(OH)D levels at all timepoints after six months, maintaining levels above 75 nmol/L throughout the year. This regimen showed no increase in all-cause mortality, with a risk ratio (95% CI) of 0.95 (0.87-1.04). Likewise, it did not significantly reduce the risks of falls and fractures, with risk ratios of 1.02 (0.98-1.05) and 0.95 (0.87-1.04) respectively. Although one-year intermittent administration significantly increased the concentration of 25(OH)D in serum, further research is needed to determine if this method would increase the incidence of falls. Therefore, it is not recommended at this stage due to the lack of demonstrated safety in additional relevant RCTs. This study had been registered on PROSPERO (CRD42022363229). https://www.bjbms.org/ojs/index.php/bjbms/article/view/10449vitamin D325(OH)Doralload doseintermittent elderly |
| spellingShingle | Xiaoyang Tao Wupeng Yang Qinxin Zhang Yongjiang Wang Feng Gao Yuehan Wang Tingxin Zhang Hao Liu Jindong Chen Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis Biomolecules & Biomedicine vitamin D3 25(OH)D oral load dose intermittent elderly |
| title | Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis |
| title_full | Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis |
| title_fullStr | Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis |
| title_full_unstemmed | Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis |
| title_short | Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis |
| title_sort | effects of intermittent overload doses of oral vitamin d3 on serum 25 oh d concentrations and the incidence rates of fractures falls and mortality in elderly individuals a systematic review and meta analysis |
| topic | vitamin D3 25(OH)D oral load dose intermittent elderly |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10449 |
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