The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes
Introduction[18F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [18F...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1236751/full |
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| author | Hélène Fank Laurent Weekers Pierre Lovinfosse Hans Pottel Laurence Seidel Alexandre Jadoul Antoine Bouquegneau Catherine Bonvoisin Christophe Bovy Christophe Bovy Stephanie Grosch Stephanie Grosch Pauline Erpicum Pauline Erpicum Roland Hustinx François Jouret |
| author_facet | Hélène Fank Laurent Weekers Pierre Lovinfosse Hans Pottel Laurence Seidel Alexandre Jadoul Antoine Bouquegneau Catherine Bonvoisin Christophe Bovy Christophe Bovy Stephanie Grosch Stephanie Grosch Pauline Erpicum Pauline Erpicum Roland Hustinx François Jouret |
| author_sort | Hélène Fank |
| collection | DOAJ |
| description | Introduction[18F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [18F]FDG PET/CT at one year post suspected AR.MethodsFrom 2012 to 2019, 114 [18F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent per cause transplant biopsies. Ordinal logistic regression assessed the correlation between the extent of histological inflammation and the mean standardized [18F]FDG uptake values (mSUVmean). Functional outcomes of kidney allografts were evaluated at one year post per cause biopsy and correlated to mSUVmean.ResultsA significant correlation between mSUVmean and acute Banff score was found, with an adjusted R2 of 0.25. The mSUVmean was significantly different between subgroups of “total i”, with 2.30 ± 0.71 in score 3 vs. 1.68 ± 0.24 in score 0. Neither the function nor the survival of the graft at one year was statistically related to mSUVmean.Discussion[18F]FDG-PET/CT may help noninvasively assess the severity of kidney allograft inflammation in KTRs with suspected AR, but it does not predict graft outcomes at one year. |
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| last_indexed | 2025-03-21T01:16:03Z |
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| series | Frontiers in Transplantation |
| spelling | doaj.art-05210a176e2e41319dfd666e07ec04602024-08-03T02:40:24ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402023-08-01210.3389/frtra.2023.12367511236751The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomesHélène Fank0Laurent Weekers1Pierre Lovinfosse2Hans Pottel3Laurence Seidel4Alexandre Jadoul5Antoine Bouquegneau6Catherine Bonvoisin7Christophe Bovy8Christophe Bovy9Stephanie Grosch10Stephanie Grosch11Pauline Erpicum12Pauline Erpicum13Roland Hustinx14François Jouret15Division of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nuclear Medicine and Oncological Imaging, University of Liège Hospital (ULiège CHU), Liège, BelgiumDepartment of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk (KULAK), Kortrijk, BelgiumDepartment of Medico-Economic Information and Biostatistic, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nuclear Medicine and Oncological Imaging, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Renal Pathology, Unilab, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Renal Pathology, Unilab, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Renal Pathology, Unilab, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nuclear Medicine and Oncological Imaging, University of Liège Hospital (ULiège CHU), Liège, BelgiumDivision of Nephrology, Department of Internal Medicine, University of Liège Hospital (ULiège CHU), Liège, BelgiumIntroduction[18F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [18F]FDG PET/CT at one year post suspected AR.MethodsFrom 2012 to 2019, 114 [18F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent per cause transplant biopsies. Ordinal logistic regression assessed the correlation between the extent of histological inflammation and the mean standardized [18F]FDG uptake values (mSUVmean). Functional outcomes of kidney allografts were evaluated at one year post per cause biopsy and correlated to mSUVmean.ResultsA significant correlation between mSUVmean and acute Banff score was found, with an adjusted R2 of 0.25. The mSUVmean was significantly different between subgroups of “total i”, with 2.30 ± 0.71 in score 3 vs. 1.68 ± 0.24 in score 0. Neither the function nor the survival of the graft at one year was statistically related to mSUVmean.Discussion[18F]FDG-PET/CT may help noninvasively assess the severity of kidney allograft inflammation in KTRs with suspected AR, but it does not predict graft outcomes at one year.https://www.frontiersin.org/articles/10.3389/frtra.2023.1236751/fullkidney transplantationacute rejectionper cause biopsy18F-fluorodeoxyglucosepositron emission tomographydiagnosis |
| spellingShingle | Hélène Fank Laurent Weekers Pierre Lovinfosse Hans Pottel Laurence Seidel Alexandre Jadoul Antoine Bouquegneau Catherine Bonvoisin Christophe Bovy Christophe Bovy Stephanie Grosch Stephanie Grosch Pauline Erpicum Pauline Erpicum Roland Hustinx François Jouret The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes Frontiers in Transplantation kidney transplantation acute rejection per cause biopsy 18F-fluorodeoxyglucose positron emission tomography diagnosis |
| title | The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| title_full | The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| title_fullStr | The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| title_full_unstemmed | The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| title_short | The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| title_sort | uptake of 18f fluorodeoxyglucose by the renal allograft correlates with the acute banff scores of cortex inflammation but not with the 1 year graft outcomes |
| topic | kidney transplantation acute rejection per cause biopsy 18F-fluorodeoxyglucose positron emission tomography diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1236751/full |
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