Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular, exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in the diagnosis, prevention, and treatment of many diseases. In addition, through the combination of nanotechnology and biotechnolo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.590470/full |
| _version_ | 1818608013880066048 |
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| author | Wumei Wei Qiang Ao Xiaohong Wang Yue Cao Yanying Liu Song Guo Zheng Xiaohong Tian |
| author_facet | Wumei Wei Qiang Ao Xiaohong Wang Yue Cao Yanying Liu Song Guo Zheng Xiaohong Tian |
| author_sort | Wumei Wei |
| collection | DOAJ |
| description | As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular, exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in the diagnosis, prevention, and treatment of many diseases. In addition, through the combination of nanotechnology and biotechnology, exosomes have emerged as innovative tools for the development of nanomedicine. This review focuses on a profound summarization of MSC-exosomes as a powerful tool in bionanomedicine. It systemically summarizes the role of MSC-exosomes as a nanocarrier, drug loading and tissue engineering, and their potential contribution in a series of diseases as well as the advantages of exosomes over stem cells and synthetic nanoparticles and potential disadvantages. The in-depth understanding of the functions and mechanisms of exosomes provides insights into the basic research and clinical transformation in the field of nanomedicine. |
| first_indexed | 2024-12-16T14:35:54Z |
| format | Article |
| id | doaj.art-0521b5f4e3f247779bdbd025e3d918ea |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-16T14:35:54Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0521b5f4e3f247779bdbd025e3d918ea2022-12-21T22:28:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-01-011110.3389/fphar.2020.590470590470Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in NanomedicineWumei Wei0Qiang Ao1Xiaohong Wang2Yue Cao3Yanying Liu4Song Guo Zheng5Xiaohong Tian6Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaInstitute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, ChinaDepartment of Internal Medicine, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, United StatesDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaAs nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular, exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in the diagnosis, prevention, and treatment of many diseases. In addition, through the combination of nanotechnology and biotechnology, exosomes have emerged as innovative tools for the development of nanomedicine. This review focuses on a profound summarization of MSC-exosomes as a powerful tool in bionanomedicine. It systemically summarizes the role of MSC-exosomes as a nanocarrier, drug loading and tissue engineering, and their potential contribution in a series of diseases as well as the advantages of exosomes over stem cells and synthetic nanoparticles and potential disadvantages. The in-depth understanding of the functions and mechanisms of exosomes provides insights into the basic research and clinical transformation in the field of nanomedicine.https://www.frontiersin.org/articles/10.3389/fphar.2020.590470/fullNanomedicine1mesenchymal stem Cells2exosomes3mesenchymal stem cell-derived exosomes4extracellular vesicles5 |
| spellingShingle | Wumei Wei Qiang Ao Xiaohong Wang Yue Cao Yanying Liu Song Guo Zheng Xiaohong Tian Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine Frontiers in Pharmacology Nanomedicine1 mesenchymal stem Cells2 exosomes3 mesenchymal stem cell-derived exosomes4 extracellular vesicles5 |
| title | Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine |
| title_full | Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine |
| title_fullStr | Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine |
| title_full_unstemmed | Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine |
| title_short | Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine |
| title_sort | mesenchymal stem cell derived exosomes a promising biological tool in nanomedicine |
| topic | Nanomedicine1 mesenchymal stem Cells2 exosomes3 mesenchymal stem cell-derived exosomes4 extracellular vesicles5 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.590470/full |
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