Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis
Abstract Background Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological test s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-04-01
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| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13550-018-0385-5 |
| _version_ | 1818485321958948864 |
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| author | Canan Güvenç Patrick Dupont Jan Van den Stock Laura Seynaeve Kathleen Porke Eva Dries Karen Van Bouwel Johannes van Loon Tom Theys Karolien E. Goffin Wim Van Paesschen |
| author_facet | Canan Güvenç Patrick Dupont Jan Van den Stock Laura Seynaeve Kathleen Porke Eva Dries Karen Van Bouwel Johannes van Loon Tom Theys Karolien E. Goffin Wim Van Paesschen |
| author_sort | Canan Güvenç |
| collection | DOAJ |
| description | Abstract Background Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological test scores in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), who were rendered seizure-free after epilepsy surgery. Results Thirteen patients were included. All had neuropsychological testing and an interictal FDG-PET scan of the brain pre- and postoperative. Correlations between changes in neuropsychological test scores and metabolism were examined using statistical parametric mapping (SPM). There were no significant changes in the neuropsychological test scores pre- and postoperatively at the group level. Decreased metabolism was observed in the left mesial temporal regions and occipital lobe. Increased metabolism was observed in the bi-frontal and right parietal lobes, temporal lobes, occipital lobes, thalamus, cerebellum, and vermis. In these regions, we did not find a correlation between changes in metabolism and neuropsychological test scores. A significant negative correlation, however, was found between metabolic changes in the precuneus and Boston Naming Test (BNT) scores. Conclusions There are significant metabolic decreases in the left mesial temporal regions and increases in the bi-frontal lobes; right parietal, temporal, and occipital lobes; right thalamus; cerebellum; and vermis in patients with left MTLE-HS who were rendered seizure-free after epilepsy surgery. We could not confirm that these changes translate into significant cognitive changes. A significant negative correlation was found between changes in confrontation naming and changes in metabolism in the precuneus. We speculate that the precuneus may play a compensatory role in patients with postoperative naming difficulties after left TLE surgery. Understanding of these neural mechanisms may aid in designing cognitive rehabilitation strategies. |
| first_indexed | 2024-12-10T16:07:13Z |
| format | Article |
| id | doaj.art-052202a691464cae9faebf52237e9411 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-10T16:07:13Z |
| publishDate | 2018-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-052202a691464cae9faebf52237e94112022-12-22T01:42:12ZengSpringerOpenEJNMMI Research2191-219X2018-04-01811710.1186/s13550-018-0385-5Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosisCanan Güvenç0Patrick Dupont1Jan Van den Stock2Laura Seynaeve3Kathleen Porke4Eva Dries5Karen Van Bouwel6Johannes van Loon7Tom Theys8Karolien E. Goffin9Wim Van Paesschen10Department of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenLaboratory for Translational Neuropsychiatry, KU LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenDepartment of Neurosurgery, University Hospitals and KU LeuvenDepartment of Neurosurgery, University Hospitals and KU LeuvenNuclear Medicine and Molecular Imaging, University Hospitals LeuvenDepartment of Neurology, Laboratory for Epilepsy Research, University Hospitals and KU LeuvenAbstract Background Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological test scores in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), who were rendered seizure-free after epilepsy surgery. Results Thirteen patients were included. All had neuropsychological testing and an interictal FDG-PET scan of the brain pre- and postoperative. Correlations between changes in neuropsychological test scores and metabolism were examined using statistical parametric mapping (SPM). There were no significant changes in the neuropsychological test scores pre- and postoperatively at the group level. Decreased metabolism was observed in the left mesial temporal regions and occipital lobe. Increased metabolism was observed in the bi-frontal and right parietal lobes, temporal lobes, occipital lobes, thalamus, cerebellum, and vermis. In these regions, we did not find a correlation between changes in metabolism and neuropsychological test scores. A significant negative correlation, however, was found between metabolic changes in the precuneus and Boston Naming Test (BNT) scores. Conclusions There are significant metabolic decreases in the left mesial temporal regions and increases in the bi-frontal lobes; right parietal, temporal, and occipital lobes; right thalamus; cerebellum; and vermis in patients with left MTLE-HS who were rendered seizure-free after epilepsy surgery. We could not confirm that these changes translate into significant cognitive changes. A significant negative correlation was found between changes in confrontation naming and changes in metabolism in the precuneus. We speculate that the precuneus may play a compensatory role in patients with postoperative naming difficulties after left TLE surgery. Understanding of these neural mechanisms may aid in designing cognitive rehabilitation strategies.http://link.springer.com/article/10.1186/s13550-018-0385-5FDG-PET metabolismNeuropsychological test scores |
| spellingShingle | Canan Güvenç Patrick Dupont Jan Van den Stock Laura Seynaeve Kathleen Porke Eva Dries Karen Van Bouwel Johannes van Loon Tom Theys Karolien E. Goffin Wim Van Paesschen Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis EJNMMI Research FDG-PET metabolism Neuropsychological test scores |
| title | Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| title_full | Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| title_fullStr | Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| title_full_unstemmed | Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| title_short | Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| title_sort | correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis |
| topic | FDG-PET metabolism Neuropsychological test scores |
| url | http://link.springer.com/article/10.1186/s13550-018-0385-5 |
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