Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival
Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been found in end-stage heart failure (HF) patients prior...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/1/61 |
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| author | Patricia van den Hoogen Manon M. H. Huibers Floor W. van den Dolder Roel de Weger Erica Siera-de Koning Marish I. F. Oerlemans Nicolaas de Jonge Linda W. van Laake Pieter A. Doevendans Joost. P. G. Sluijter Aryan Vink Saskia C. A. de Jager |
| author_facet | Patricia van den Hoogen Manon M. H. Huibers Floor W. van den Dolder Roel de Weger Erica Siera-de Koning Marish I. F. Oerlemans Nicolaas de Jonge Linda W. van Laake Pieter A. Doevendans Joost. P. G. Sluijter Aryan Vink Saskia C. A. de Jager |
| author_sort | Patricia van den Hoogen |
| collection | DOAJ |
| description | Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been found in end-stage heart failure (HF) patients prior to HTx. In this study, we aimed to determine whether increased circulating immunoglobulin levels prior to transplantation are associated with poor post-HTx survival. Pre-and post-HTx plasma samples of 36 cardiac transplant recipient patients were used to determine circulating immunoglobulin levels. In addition, epicardial tissue was collected to determine immunoglobulin deposition in cardiac tissue and assess signs and severity of graft rejection. High levels of IgG1 and IgG2 prior to HTx were associated with a shorter survival post-HTx. Immunoglobulin deposition in cardiac tissue was significantly elevated in patients with a survival of less than 3 years. Patients with high plasma IgG levels pre-HTx also had significantly higher plasma levels after HTx. Furthermore, high pre-HTX levels of IgG1 and IgG2 levels were also significantly increased in patients with inflammatory infiltrate in CAV lesions. Altogether the results of this proof-of-concept study suggest that an activated immune response prior to transplantation negatively affects graft survival. |
| first_indexed | 2024-03-09T13:31:47Z |
| format | Article |
| id | doaj.art-052311861a394f7db06126baef2e60c0 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T13:31:47Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-052311861a394f7db06126baef2e60c02023-11-30T21:16:48ZengMDPI AGBiology2079-77372022-12-011216110.3390/biology12010061Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation SurvivalPatricia van den Hoogen0Manon M. H. Huibers1Floor W. van den Dolder2Roel de Weger3Erica Siera-de Koning4Marish I. F. Oerlemans5Nicolaas de Jonge6Linda W. van Laake7Pieter A. Doevendans8Joost. P. G. Sluijter9Aryan Vink10Saskia C. A. de Jager11Laboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsLaboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, Circulatory Health Laboratory, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsLaboratory for Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsCardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been found in end-stage heart failure (HF) patients prior to HTx. In this study, we aimed to determine whether increased circulating immunoglobulin levels prior to transplantation are associated with poor post-HTx survival. Pre-and post-HTx plasma samples of 36 cardiac transplant recipient patients were used to determine circulating immunoglobulin levels. In addition, epicardial tissue was collected to determine immunoglobulin deposition in cardiac tissue and assess signs and severity of graft rejection. High levels of IgG1 and IgG2 prior to HTx were associated with a shorter survival post-HTx. Immunoglobulin deposition in cardiac tissue was significantly elevated in patients with a survival of less than 3 years. Patients with high plasma IgG levels pre-HTx also had significantly higher plasma levels after HTx. Furthermore, high pre-HTX levels of IgG1 and IgG2 levels were also significantly increased in patients with inflammatory infiltrate in CAV lesions. Altogether the results of this proof-of-concept study suggest that an activated immune response prior to transplantation negatively affects graft survival.https://www.mdpi.com/2079-7737/12/1/61HTXimmunoglobulingraft survivalheart failurecardiac allograft vasculopathyrejection |
| spellingShingle | Patricia van den Hoogen Manon M. H. Huibers Floor W. van den Dolder Roel de Weger Erica Siera-de Koning Marish I. F. Oerlemans Nicolaas de Jonge Linda W. van Laake Pieter A. Doevendans Joost. P. G. Sluijter Aryan Vink Saskia C. A. de Jager Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival Biology HTX immunoglobulin graft survival heart failure cardiac allograft vasculopathy rejection |
| title | Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival |
| title_full | Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival |
| title_fullStr | Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival |
| title_full_unstemmed | Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival |
| title_short | Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival |
| title_sort | elevated plasma immunoglobulin levels prior to heart transplantation are associated with poor post transplantation survival |
| topic | HTX immunoglobulin graft survival heart failure cardiac allograft vasculopathy rejection |
| url | https://www.mdpi.com/2079-7737/12/1/61 |
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