Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial
Background: Hyperhomocysteinemia is considered a risk factor for atherosclerosis and some other vascular diseases such as Buerger’s disease. Objective: The aim of this study was to measure the Homocysteine levels in 3 different groups of participants (Buerger’s disease, atherosclerosis patients,...
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| Format: | Article |
| Language: | English |
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Electronic Physician
2016-10-01
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| Series: | Electronic Physician |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133041/ |
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| author | Mohammad Hadi Saeed Modaghegh Hassan Ravari Mohammad Zare Haghighi Ata’ollah Rajabnejad |
| author_facet | Mohammad Hadi Saeed Modaghegh Hassan Ravari Mohammad Zare Haghighi Ata’ollah Rajabnejad |
| author_sort | Mohammad Hadi Saeed Modaghegh |
| collection | DOAJ |
| description | Background: Hyperhomocysteinemia is considered a risk factor for atherosclerosis and some other vascular
diseases such as Buerger’s disease.
Objective: The aim of this study was to measure the Homocysteine levels in 3 different groups of participants
(Buerger’s disease, atherosclerosis patients, and healthy cases) and determine the therapeutic effect of folic acid
therapy on homocysteine levels for these three groups.
Methods: This nonrandomized clinical trial study was conducted in the vascular and endovascular surgery
research center of Mashhad University of Medical Sciences in Mashhad, Iran. This interventional study consisted
of 44 participants of which 22 patients had Buerger’s disease and a control group of 22 healthy individuals, all of
which were enrolled in this study. All of the study’s participants had their serum homocysteine levels measured
both before and after 12 weeks of folic acid (5mg/day) therapy. The data analysis used fo data analysis was a Chi
square and t-test or their non-parametrical equivalents for data analysis by means of Statistical Package for the
Social Sciences (SPSS) version 16.
Results: The homocysteine levels were found to be significantly higher in patients with Buerger’s disease as
compared to other groups before treatment with folic acid (Buerger = 21.8 ± 8.5 Mm/L, atherosclerosis = 17.3 ±
6.9, healthy = 13.8 ± 3.1; p < 0.001). After treatment with folic acid at 5 mg/daily for 12 weeks, the new plasma
homocysteine levels did not show any significant difference (p = 0.38) between the Buerger’s disease group (14.6
± 4.5 Mm/L) and atherosclerosis group (13.9 ± 4.7), but it was found to besignificantly higher in both groups
when compared to the healthy group (10.7 ± 3.9, p<0.05). The plasma homocysteine level was reduced
significantly when compared to its initial level in all 3 groups. The comparison of differences among three groups
was found not to be significant (p=0.41).
Conclusions: It seems that supplementary therapy with folic acid at a dose of 5 mg daily may reduce the serum
homocysteine levels significantly and may have a role in the development of vascular diseases such as Buerger’s
disease. We suggest that folic acid should be considered as a routine agent in the Buerger’s disease therapeutic
regime.
Clinical trial registration: The trial was registered at the Thai Clinical Trials Registry
(http://www.clinicaltrials.in.th) with the ID: TCTR20160601003.
Funding: This study was not funded by any organization. |
| first_indexed | 2024-12-20T09:38:49Z |
| format | Article |
| id | doaj.art-0527b6a5f11b44daae3476de95c98c7e |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-12-20T09:38:49Z |
| publishDate | 2016-10-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-0527b6a5f11b44daae3476de95c98c7e2022-12-21T19:44:55ZengElectronic PhysicianElectronic Physician2008-58422008-58422016-10-018103138314310.19082/3138Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trialMohammad Hadi Saeed ModagheghHassan RavariMohammad Zare HaghighiAta’ollah RajabnejadBackground: Hyperhomocysteinemia is considered a risk factor for atherosclerosis and some other vascular diseases such as Buerger’s disease. Objective: The aim of this study was to measure the Homocysteine levels in 3 different groups of participants (Buerger’s disease, atherosclerosis patients, and healthy cases) and determine the therapeutic effect of folic acid therapy on homocysteine levels for these three groups. Methods: This nonrandomized clinical trial study was conducted in the vascular and endovascular surgery research center of Mashhad University of Medical Sciences in Mashhad, Iran. This interventional study consisted of 44 participants of which 22 patients had Buerger’s disease and a control group of 22 healthy individuals, all of which were enrolled in this study. All of the study’s participants had their serum homocysteine levels measured both before and after 12 weeks of folic acid (5mg/day) therapy. The data analysis used fo data analysis was a Chi square and t-test or their non-parametrical equivalents for data analysis by means of Statistical Package for the Social Sciences (SPSS) version 16. Results: The homocysteine levels were found to be significantly higher in patients with Buerger’s disease as compared to other groups before treatment with folic acid (Buerger = 21.8 ± 8.5 Mm/L, atherosclerosis = 17.3 ± 6.9, healthy = 13.8 ± 3.1; p < 0.001). After treatment with folic acid at 5 mg/daily for 12 weeks, the new plasma homocysteine levels did not show any significant difference (p = 0.38) between the Buerger’s disease group (14.6 ± 4.5 Mm/L) and atherosclerosis group (13.9 ± 4.7), but it was found to besignificantly higher in both groups when compared to the healthy group (10.7 ± 3.9, p<0.05). The plasma homocysteine level was reduced significantly when compared to its initial level in all 3 groups. The comparison of differences among three groups was found not to be significant (p=0.41). Conclusions: It seems that supplementary therapy with folic acid at a dose of 5 mg daily may reduce the serum homocysteine levels significantly and may have a role in the development of vascular diseases such as Buerger’s disease. We suggest that folic acid should be considered as a routine agent in the Buerger’s disease therapeutic regime. Clinical trial registration: The trial was registered at the Thai Clinical Trials Registry (http://www.clinicaltrials.in.th) with the ID: TCTR20160601003. Funding: This study was not funded by any organization.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133041/Buerger’s diseaseAtherosclerosisHomocysteine |
| spellingShingle | Mohammad Hadi Saeed Modaghegh Hassan Ravari Mohammad Zare Haghighi Ata’ollah Rajabnejad Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial Electronic Physician Buerger’s disease Atherosclerosis Homocysteine |
| title | Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial |
| title_full | Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial |
| title_fullStr | Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial |
| title_full_unstemmed | Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial |
| title_short | Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial |
| title_sort | effect of folic acid therapy on homocysteine level in patients with atherosclerosis or buerger s disease and in healthy individuals a clinical trial |
| topic | Buerger’s disease Atherosclerosis Homocysteine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133041/ |
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