Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy
The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force micros...
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| Format: | Article |
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Beilstein-Institut
2021-12-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.12.101 |
| _version_ | 1819283453259022336 |
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| author | Xiaoteng Liang Shuai Liu Xiuchao Wang Dan Xia Qiang Li |
| author_facet | Xiaoteng Liang Shuai Liu Xiuchao Wang Dan Xia Qiang Li |
| author_sort | Xiaoteng Liang |
| collection | DOAJ |
| description | The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells. |
| first_indexed | 2024-12-24T01:31:43Z |
| format | Article |
| id | doaj.art-0527e2af8b9548d8b0a673666bd0c4a0 |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-24T01:31:43Z |
| publishDate | 2021-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-0527e2af8b9548d8b0a673666bd0c4a02022-12-21T17:22:19ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862021-12-011211372137910.3762/bjnano.12.1012190-4286-12-101Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopyXiaoteng Liang0Shuai Liu1Xiuchao Wang2Dan Xia3Qiang Li4School of Materials Science and Engineering, Hebei University of Technology and Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Tianjin, 300130, ChinaSchool of Materials Science and Engineering, Hebei University of Technology and Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Tianjin, 300130, ChinaTianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, ChinaSchool of Materials Science and Engineering, Hebei University of Technology and Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Tianjin, 300130, ChinaKey Laboratory of Colloid and Interface Chemistry of Ministry of Education, And School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Shandong, ChinaThe mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells.https://doi.org/10.3762/bjnano.12.101anticancer drugatomic force microscopynanomechanical propertiespancreatic cancer cells |
| spellingShingle | Xiaoteng Liang Shuai Liu Xiuchao Wang Dan Xia Qiang Li Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy Beilstein Journal of Nanotechnology anticancer drug atomic force microscopy nanomechanical properties pancreatic cancer cells |
| title | Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| title_full | Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| title_fullStr | Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| title_full_unstemmed | Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| title_short | Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| title_sort | alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy |
| topic | anticancer drug atomic force microscopy nanomechanical properties pancreatic cancer cells |
| url | https://doi.org/10.3762/bjnano.12.101 |
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