Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies
Background: Invasive micropapillary carcinoma (IMPC) is a rare histological subtype of breast cancer. The outcome of IMPC remains controversial; we conducted a meta-analysis of propensity score matching (PSM) studies to evaluate the prognostic difference between IMPC and invasive ductal carcinoma (I...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-06-01
|
| Series: | Breast |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977620300564 |
| _version_ | 1819203157175042048 |
|---|---|
| author | Feng Ye Ping Yu Na Li Anli Yang Xinhua Xie Hailin Tang Peng Liu |
| author_facet | Feng Ye Ping Yu Na Li Anli Yang Xinhua Xie Hailin Tang Peng Liu |
| author_sort | Feng Ye |
| collection | DOAJ |
| description | Background: Invasive micropapillary carcinoma (IMPC) is a rare histological subtype of breast cancer. The outcome of IMPC remains controversial; we conducted a meta-analysis of propensity score matching (PSM) studies to evaluate the prognostic difference between IMPC and invasive ductal carcinoma (IDC). Methods: We searched PubMed, EMBASE and the Cochrane library for PSM studies comparing survival data between IMPC and IDC. The summarized odds ratios (ORs) and 95% confidence interval (95% CI) are calculated by STATA software utilizing fixed-effect or random-effect models, depending on the heterogeneity of the eligible studies. Results: Eight PSM studies including 2102 IMPC patients are included in the meta-analysis. Compared with IDC, IMPC has a similar overall survival (OS) (estimated OR = 0.87, 95% CI: 0.61–1.25), but a shorter relapse free survival (RFS) (estimated OR = 1.31, 95% CI: 1.06–1.61); the shorter RFS might owe to the significantly higher loco-regional recurrence rate of IMPC (estimated OR = 3.60, 95% CI: 1.99–6.52). Funnel plots and Egger’s tests are used to evaluate publication bias and the p value for OS and RFS are 0.036 and 0.564 respectively. Conclusions: Our results demonstrate that compared with IDC, IMPC exhibits a similar, even favorite OS, but a shorter RFS; and the shorter RFS might owe to the significantly higher loco-regional recurrence rate of IMPC. These results could contribute to the individualized therapy and follow-up strategies for IMPC patients. |
| first_indexed | 2024-12-23T04:15:27Z |
| format | Article |
| id | doaj.art-0529757011c5417aad178d044b47e995 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-12-23T04:15:27Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-0529757011c5417aad178d044b47e9952022-12-21T18:00:22ZengElsevierBreast1532-30802020-06-01511120Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studiesFeng Ye0Ping Yu1Na Li2Anli Yang3Xinhua Xie4Hailin Tang5Peng Liu6Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaDepartment of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaDepartment of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaDepartment of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaDepartment of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaCorresponding author author. Department of Breast Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, 510060, People’s Republic of China.; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaCorresponding author author. Department of Breast Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, 510060, People’s Republic of China.; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, ChinaBackground: Invasive micropapillary carcinoma (IMPC) is a rare histological subtype of breast cancer. The outcome of IMPC remains controversial; we conducted a meta-analysis of propensity score matching (PSM) studies to evaluate the prognostic difference between IMPC and invasive ductal carcinoma (IDC). Methods: We searched PubMed, EMBASE and the Cochrane library for PSM studies comparing survival data between IMPC and IDC. The summarized odds ratios (ORs) and 95% confidence interval (95% CI) are calculated by STATA software utilizing fixed-effect or random-effect models, depending on the heterogeneity of the eligible studies. Results: Eight PSM studies including 2102 IMPC patients are included in the meta-analysis. Compared with IDC, IMPC has a similar overall survival (OS) (estimated OR = 0.87, 95% CI: 0.61–1.25), but a shorter relapse free survival (RFS) (estimated OR = 1.31, 95% CI: 1.06–1.61); the shorter RFS might owe to the significantly higher loco-regional recurrence rate of IMPC (estimated OR = 3.60, 95% CI: 1.99–6.52). Funnel plots and Egger’s tests are used to evaluate publication bias and the p value for OS and RFS are 0.036 and 0.564 respectively. Conclusions: Our results demonstrate that compared with IDC, IMPC exhibits a similar, even favorite OS, but a shorter RFS; and the shorter RFS might owe to the significantly higher loco-regional recurrence rate of IMPC. These results could contribute to the individualized therapy and follow-up strategies for IMPC patients.http://www.sciencedirect.com/science/article/pii/S0960977620300564Invasive micropapillary carcinomaBreast cancerPrognosisPSM studyMeta-analysis |
| spellingShingle | Feng Ye Ping Yu Na Li Anli Yang Xinhua Xie Hailin Tang Peng Liu Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies Breast Invasive micropapillary carcinoma Breast cancer Prognosis PSM study Meta-analysis |
| title | Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies |
| title_full | Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies |
| title_fullStr | Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies |
| title_full_unstemmed | Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies |
| title_short | Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: A meta-analysis of PSM studies |
| title_sort | prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast a meta analysis of psm studies |
| topic | Invasive micropapillary carcinoma Breast cancer Prognosis PSM study Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0960977620300564 |
| work_keys_str_mv | AT fengye prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT pingyu prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT nali prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT anliyang prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT xinhuaxie prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT hailintang prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies AT pengliu prognosisofinvasivemicropapillarycarcinomacomparedwithinvasiveductalcarcinomainbreastametaanalysisofpsmstudies |