Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls
Abstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02192-2 |
| _version_ | 1818596160893353984 |
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| author | Jikang Shi Siyu Liu Yanbo Guo Sainan Liu Jiayi Xu Lingfeng Pan Yueyang Hu Yawen Liu Yi Cheng |
| author_facet | Jikang Shi Siyu Liu Yanbo Guo Sainan Liu Jiayi Xu Lingfeng Pan Yueyang Hu Yawen Liu Yi Cheng |
| author_sort | Jikang Shi |
| collection | DOAJ |
| description | Abstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). Conclusions We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension. |
| first_indexed | 2024-12-16T11:27:30Z |
| format | Article |
| id | doaj.art-0529d6105d0b48ab9aafd1245c96085b |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-16T11:27:30Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-0529d6105d0b48ab9aafd1245c96085b2022-12-21T22:33:19ZengBMCBMC Cardiovascular Disorders1471-22612021-08-0121111110.1186/s12872-021-02192-2Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controlsJikang Shi0Siyu Liu1Yanbo Guo2Sainan Liu3Jiayi Xu4Lingfeng Pan5Yueyang Hu6Yawen Liu7Yi Cheng8Department of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Children and Adolescence Health, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityThe Cardiovascular Center, The First Hospital of Jilin UniversityAbstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). Conclusions We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.https://doi.org/10.1186/s12872-021-02192-2HypertensioneNOSrs1799983PolymorphismMeta-analysis |
| spellingShingle | Jikang Shi Siyu Liu Yanbo Guo Sainan Liu Jiayi Xu Lingfeng Pan Yueyang Hu Yawen Liu Yi Cheng Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls BMC Cardiovascular Disorders Hypertension eNOS rs1799983 Polymorphism Meta-analysis |
| title | Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls |
| title_full | Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls |
| title_fullStr | Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls |
| title_full_unstemmed | Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls |
| title_short | Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls |
| title_sort | association between enos rs1799983 polymorphism and hypertension a meta analysis involving 14 185 cases and 13 407 controls |
| topic | Hypertension eNOS rs1799983 Polymorphism Meta-analysis |
| url | https://doi.org/10.1186/s12872-021-02192-2 |
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