The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

The prion protein (PrPC) is a cell surface glycoprotein mainly expressed in neurons, whose misfolded isoforms generate the prion responsible for incurable neurodegenerative disorders. Whereas PrPC involvement in prion propagation is well established, PrPC physiological function is still enigmatic de...

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Bibliographic Details
Main Authors: Agnese eDe Mario, Angela eCastellani, Caterina ePeggion, Maria Lina eMassimino, Dmitry eLim, Andrew Francis Hill, Maria Catia eSorgato, Alessandro eBertoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer's disease
prion protein
store-operated Ca2+ entry
Ca2+
cerebellar granule neurons
abeta oligomers
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00416/full

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