Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof

Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof

Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins, STL is expected to find a wide range of appl...

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Bibliographic Details
Main Authors: Clarence T. T. Wong, Tianlu eLi, Hiu Yung eLam, Yinfeng eZhang, Xuechen eLI
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Chemistry
Subjects:
protein synthesis
solid phase peptide synthesis
Peptide Ligation
Chemoselectivity
Peptide synthesis.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fchem.2014.00028/full

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