An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
This 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1127511/full |
| _version_ | 1797860991108644864 |
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| author | Jan Čermák Slavomír Pietrucha Alexander Nawka Paola Lipone Alessandro Ruggieri Annalisa Bonelli Alessandro Comandini Agnese Cattaneo |
| author_facet | Jan Čermák Slavomír Pietrucha Alexander Nawka Paola Lipone Alessandro Ruggieri Annalisa Bonelli Alessandro Comandini Agnese Cattaneo |
| author_sort | Jan Čermák |
| collection | DOAJ |
| description | This 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in patients with major depressive disorder (MDD) treated with trazodone once a day (OAD). Overall, 11 out of 30 planned patients were enrolled. Passive parameters measured by the wearable device included number of steps, distance walked, calories burned, and sleep quality. A relationship between the sleep score (derived from passively measured data) and MADRS score was observed, as was a relationship between data collected actively (assessing depression, sleep, anxiety, and warning signs) and MADRS score. Despite the limited sample size, the efficacy and safety results were consistent with those previously reported for trazodone. The small population in this study limits the conclusions that can be drawn about the correlation between the digital phenotyping approach and traditional clinical evaluation; however, the positive trends observed suggest the need to increase synergies among clinicians, patients, and researchers to overcome the cultural barriers toward implementation of digital tools in the clinical setting. This study is a step toward the use of digital data in monitoring symptoms of depression, and the preliminary data obtained encourage further investigations of a larger population of patients monitored over a longer period of time. |
| first_indexed | 2024-04-09T21:54:51Z |
| format | Article |
| id | doaj.art-052e2975bcd14c8f9557fb09387bc7e3 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T21:54:51Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-052e2975bcd14c8f9557fb09387bc7e32023-03-24T05:51:22ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-03-011410.3389/fpsyt.2023.11275111127511An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with TrazodoneJan Čermák0Slavomír Pietrucha1Alexander Nawka2Paola Lipone3Alessandro Ruggieri4Annalisa Bonelli5Alessandro Comandini6Agnese Cattaneo7Psychiatrie Říčany s.r.o., Říčany, CzechiaCentrum Duševního Zdraví—Psychiatrie s.r.o., Kutná Hora, CzechiaInstitut Neuropsychiatrické Péče (INEP) (Psychiatric Outpatient Clinic), Praha, CzechiaAngelini Pharma S.p.A., Rome, ItalyAngelini Pharma S.p.A., Rome, ItalyAngelini Pharma S.p.A., Rome, ItalyAngelini Pharma S.p.A., Rome, ItalyAngelini Pharma S.p.A., Rome, ItalyThis 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in patients with major depressive disorder (MDD) treated with trazodone once a day (OAD). Overall, 11 out of 30 planned patients were enrolled. Passive parameters measured by the wearable device included number of steps, distance walked, calories burned, and sleep quality. A relationship between the sleep score (derived from passively measured data) and MADRS score was observed, as was a relationship between data collected actively (assessing depression, sleep, anxiety, and warning signs) and MADRS score. Despite the limited sample size, the efficacy and safety results were consistent with those previously reported for trazodone. The small population in this study limits the conclusions that can be drawn about the correlation between the digital phenotyping approach and traditional clinical evaluation; however, the positive trends observed suggest the need to increase synergies among clinicians, patients, and researchers to overcome the cultural barriers toward implementation of digital tools in the clinical setting. This study is a step toward the use of digital data in monitoring symptoms of depression, and the preliminary data obtained encourage further investigations of a larger population of patients monitored over a longer period of time.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1127511/fulldigital phenotypingmental healthmajor depressive disordertrazodoneactive data collectionpassive data collection |
| spellingShingle | Jan Čermák Slavomír Pietrucha Alexander Nawka Paola Lipone Alessandro Ruggieri Annalisa Bonelli Alessandro Comandini Agnese Cattaneo An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone Frontiers in Psychiatry digital phenotyping mental health major depressive disorder trazodone active data collection passive data collection |
| title | An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone |
| title_full | An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone |
| title_fullStr | An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone |
| title_full_unstemmed | An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone |
| title_short | An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone |
| title_sort | observational pilot study using a digital phenotyping approach in patients with major depressive disorder treated with trazodone |
| topic | digital phenotyping mental health major depressive disorder trazodone active data collection passive data collection |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1127511/full |
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