Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study
Abstract Introduction Laparoscopic repeat hepatectomy (LRH) is considered to be a technically challenging procedure which has not been widely applied. This study aimed to assess the accessibility and security of LRH for patients with hepatic tumor recurrence. Methods Between January 2010 and October...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02668-1 |
| _version_ | 1818252116336050176 |
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| author | Zefeng Shen Jingwei Cai Jiaqi Gao Junhao Zheng Liye Tao Yuelong Liang Junjie Xu Xiao Liang |
| author_facet | Zefeng Shen Jingwei Cai Jiaqi Gao Junhao Zheng Liye Tao Yuelong Liang Junjie Xu Xiao Liang |
| author_sort | Zefeng Shen |
| collection | DOAJ |
| description | Abstract Introduction Laparoscopic repeat hepatectomy (LRH) is considered to be a technically challenging procedure which has not been widely applied. This study aimed to assess the accessibility and security of LRH for patients with hepatic tumor recurrence. Methods Between January 2010 and October 2020, we performed 48 LRHs and 31 open repeat hepatectomies (ORHs) for recurrent liver cancer. LRHs were matched to ORHs (1:1) using propensity score matching (PSM) created by comparing preoperative factors. The perioperative data of patients were retrospectively analyzed, including baseline data, operative time, intraoperative blood loss, pathology, days of postoperative stay, complication morbidity, and mortality within 30 days. Overall survival and recurrence-free survival rates with appropriate follow-up were obtained to evaluate the long-term outcomes. Results Compared with the ORH, LRH was related with shorter operative duration (169.9 versus 232.9 ml, p < 0.01), less intraoperative bleeding (100.0 versus 500.0 ml, p < 0.01), lower rate of blood transfusion (8.3% versus 58.1%, p < 0.01), and shorter hospitalization (5.0 versus 11.0 days, p < 0.01). The median follow-up was 31 months. The LRH 1-, 3-, and 5-year overall survival were 77.1%, 61.6%, and 46.2% versus 82.3%, 66.5%, and 29.5% for ORH (p = 0.77). The 1-, 3-, and 5-year disease-free survival rates of the two groups were 73.4%, 62.0%, and 44.3% versus 66.1%, 44.1%, and 14.7%, respectively (p = 0.22). Conclusions Laparoscopic repeated hepatectomy is safe and practicable with great short-term results for selected patients. |
| first_indexed | 2024-12-12T16:19:04Z |
| format | Article |
| id | doaj.art-052e70ec6e6b44f2893180ebb24313fd |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-12T16:19:04Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-052e70ec6e6b44f2893180ebb24313fd2022-12-22T00:19:01ZengBMCWorld Journal of Surgical Oncology1477-78192022-06-0120111010.1186/s12957-022-02668-1Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching studyZefeng Shen0Jingwei Cai1Jiaqi Gao2Junhao Zheng3Liye Tao4Yuelong Liang5Junjie Xu6Xiao Liang7Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityAbstract Introduction Laparoscopic repeat hepatectomy (LRH) is considered to be a technically challenging procedure which has not been widely applied. This study aimed to assess the accessibility and security of LRH for patients with hepatic tumor recurrence. Methods Between January 2010 and October 2020, we performed 48 LRHs and 31 open repeat hepatectomies (ORHs) for recurrent liver cancer. LRHs were matched to ORHs (1:1) using propensity score matching (PSM) created by comparing preoperative factors. The perioperative data of patients were retrospectively analyzed, including baseline data, operative time, intraoperative blood loss, pathology, days of postoperative stay, complication morbidity, and mortality within 30 days. Overall survival and recurrence-free survival rates with appropriate follow-up were obtained to evaluate the long-term outcomes. Results Compared with the ORH, LRH was related with shorter operative duration (169.9 versus 232.9 ml, p < 0.01), less intraoperative bleeding (100.0 versus 500.0 ml, p < 0.01), lower rate of blood transfusion (8.3% versus 58.1%, p < 0.01), and shorter hospitalization (5.0 versus 11.0 days, p < 0.01). The median follow-up was 31 months. The LRH 1-, 3-, and 5-year overall survival were 77.1%, 61.6%, and 46.2% versus 82.3%, 66.5%, and 29.5% for ORH (p = 0.77). The 1-, 3-, and 5-year disease-free survival rates of the two groups were 73.4%, 62.0%, and 44.3% versus 66.1%, 44.1%, and 14.7%, respectively (p = 0.22). Conclusions Laparoscopic repeated hepatectomy is safe and practicable with great short-term results for selected patients.https://doi.org/10.1186/s12957-022-02668-1LaparoscopyHepatocellular cancerHepatectomyRecurrence |
| spellingShingle | Zefeng Shen Jingwei Cai Jiaqi Gao Junhao Zheng Liye Tao Yuelong Liang Junjie Xu Xiao Liang Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study World Journal of Surgical Oncology Laparoscopy Hepatocellular cancer Hepatectomy Recurrence |
| title | Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study |
| title_full | Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study |
| title_fullStr | Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study |
| title_full_unstemmed | Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study |
| title_short | Efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy: a single-center, propensity score matching study |
| title_sort | efficacy of laparoscopic repeat hepatectomy compared with open repeat hepatectomy a single center propensity score matching study |
| topic | Laparoscopy Hepatocellular cancer Hepatectomy Recurrence |
| url | https://doi.org/10.1186/s12957-022-02668-1 |
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