The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu
Background: Iodine is a trace element that is essential for the formation of thyroid hormones. It is essential for the human life’s growth and development. The thyroid gland size and functions affected by deficient or excessive intake of iodine. Iodine excess intake was found to associating with iod...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-07-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/43645 |
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| author | Suresh Pichandi Sivakumar J Ganesh V Janakiraman P Ramadevi K |
| author_facet | Suresh Pichandi Sivakumar J Ganesh V Janakiraman P Ramadevi K |
| author_sort | Suresh Pichandi |
| collection | DOAJ |
| description | Background: Iodine is a trace element that is essential for the formation of thyroid hormones. It is essential for the human life’s growth and development. The thyroid gland size and functions affected by deficient or excessive intake of iodine. Iodine excess intake was found to associating with iodine-induced hyperthyroidism (IIH) and autoimmune thyroiditis.
Aims and Objectives: The present study was to find the hyperthyroid goiter patient nutritional status by urinary iodine excretion (UIE) measurement and correlate them with thyroid hormone and thyroid autoantibodies.
Materials and Methods: In this study, 100 adult hyperthyroid goiter ssubjects and 100 apparently normal adult subjects were conveniently recruited in this study.Urinary iodine estimation and serum TSH, fT4, fT3, AMA, and ATG were estimated,which were estimated for case and control groups.
Results: The hyperthyroid goiter patient mean UIE concentration was 278.98 μg/L and 68% of excess UIE which was found. There was significant difference in the UIE between the hyperthyroid goiter patient and control (P<0.001). The following types of goiter, based on palpation, were identified among the 100 hyperthyroid patients: Grade I – 4 %, Grade II – 63%, and Grade III – 33%. There were elevated serum AMA levelswith positive correlation of excess iodine for hyperthyroid goiter patient.
Conclusion: In this study, there were excess UIEs among patients; hence, these associated complications, namely, benign goiter (14%), thyroiditis (43%), cancer of thyroid (4%), and thyrotoxicosis (39%) were observed. |
| first_indexed | 2024-04-12T10:28:52Z |
| format | Article |
| id | doaj.art-05306f8871e747a8803234a4b3a65c97 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-12T10:28:52Z |
| publishDate | 2022-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-05306f8871e747a8803234a4b3a65c972022-12-22T03:36:53ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-07-011378286https://doi.org/10.3126/ajms.v13i7.43645The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil NaduSuresh Pichandi 0https://orcid.org/0000-0002-9254-5774Sivakumar J 1https://orcid.org/0000-0002-6944-7439Ganesh V2Janakiraman P 3https://orcid.org/0000-0002-5802-8861Ramadevi K 4https://orcid.org/0000-0003-0602-5420Associate Professor, Department of Biochemistry, Sri Venkateshwaraa Medical College and Research Center, Puducherry Associate Professor, Department of Biochemistry, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu Tutor, Department of Biochemistry, Sri Venkateshwaraa Medical College and Research Center, PuducherryTutor in Statistics, Department of Community Medicine, PES Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh Professor and Head, Department of Biochemistry, Madras Medical College and Govt. Rajivganthi General Hospital, Chennai, Tamil Nadu, India Background: Iodine is a trace element that is essential for the formation of thyroid hormones. It is essential for the human life’s growth and development. The thyroid gland size and functions affected by deficient or excessive intake of iodine. Iodine excess intake was found to associating with iodine-induced hyperthyroidism (IIH) and autoimmune thyroiditis. Aims and Objectives: The present study was to find the hyperthyroid goiter patient nutritional status by urinary iodine excretion (UIE) measurement and correlate them with thyroid hormone and thyroid autoantibodies. Materials and Methods: In this study, 100 adult hyperthyroid goiter ssubjects and 100 apparently normal adult subjects were conveniently recruited in this study.Urinary iodine estimation and serum TSH, fT4, fT3, AMA, and ATG were estimated,which were estimated for case and control groups. Results: The hyperthyroid goiter patient mean UIE concentration was 278.98 μg/L and 68% of excess UIE which was found. There was significant difference in the UIE between the hyperthyroid goiter patient and control (P<0.001). The following types of goiter, based on palpation, were identified among the 100 hyperthyroid patients: Grade I – 4 %, Grade II – 63%, and Grade III – 33%. There were elevated serum AMA levelswith positive correlation of excess iodine for hyperthyroid goiter patient. Conclusion: In this study, there were excess UIEs among patients; hence, these associated complications, namely, benign goiter (14%), thyroiditis (43%), cancer of thyroid (4%), and thyrotoxicosis (39%) were observed.https://www.nepjol.info/index.php/AJMS/article/view/43645goiteriodine-induced hyperthyroidismthyroiditisthyrotoxicosisurinary iodine excretion |
| spellingShingle | Suresh Pichandi Sivakumar J Ganesh V Janakiraman P Ramadevi K The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu Asian Journal of Medical Sciences goiter iodine-induced hyperthyroidism thyroiditis thyrotoxicosis urinary iodine excretion |
| title | The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu |
| title_full | The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu |
| title_fullStr | The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu |
| title_full_unstemmed | The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu |
| title_short | The correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of Tamil Nadu |
| title_sort | correlation between iodine nutrition and autoimmunity among hyperthyroid goiter patients in tertiary care hospital of tamil nadu |
| topic | goiter iodine-induced hyperthyroidism thyroiditis thyrotoxicosis urinary iodine excretion |
| url | https://www.nepjol.info/index.php/AJMS/article/view/43645 |
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