Evaluating risk factors for catheter-related infections in hemodialysis patients
Introduction: Catheter-related infection in the patients with end-stage renal disease (ESRD) is one of the leading causes of death. Identifying risk factors for infection, including patients’ iron profile, plays an important role in preventing this complication. Objectives: In this study, we aimed t...
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| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2022-07-01
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| Series: | Journal of Nephropharmacology |
| Subjects: | |
| Online Access: | https://jnephropharmacology.com/PDF/npj-11-e10489.pdf |
| _version_ | 1797985870068842496 |
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| author | Sepideh Hajian Moosa Seifzade |
| author_facet | Sepideh Hajian Moosa Seifzade |
| author_sort | Sepideh Hajian |
| collection | DOAJ |
| description | Introduction: Catheter-related infection in the patients with end-stage renal disease (ESRD) is one of the leading causes of death. Identifying risk factors for infection, including patients’ iron profile, plays an important role in preventing this complication. Objectives: In this study, we aimed to determine the risk factors of catheter-related infections among the ESRD patients in Qazvin, Iran. Patients and Methods: In this observational study, 41 patients with hemodialysis venous catheter-related infection (case group) and 42 patients without catheter-related infection ( control group) in Qazvin educational and medical centers were studied. The definition of functional iron deficiency anemia included ferritin <500 ng/mL and serum iron/total iron-binding capacity (TIBC) <30%. The laboratory evaluation method was based on enzyme-linked immunosorbent assay method. Definition of catheter-related infection in this study consisted of two positive results of the three cultures from blue and red catheter lines and blood at the same time with the same microorganism. Results: In studying iron parameters, a significant difference between serum iron levels and transferrin saturation in the two groups was detected (P values of 0.0016 and 0.003, respectively). Both parameters were higher in the control group. The most common microorganism causing the infection was Staphylococcus aureus (43.9%) and most of the catheters used were of temporary internal jugular vein types. The most important risk factors in the incidence of catheter infection were diabetes mellitus (OR = 5.059) and high serum iron levels (OR = 1.053). Decreased transferrin saturation levels reduced the risk of infection (OR = 0.825). Conclusion: There was a relationship between iron profile and diabetes mellitus and the increased risk of catheter-related infections. To prevent infection, patients with ESRD undergoing hemodialysis with venous catheters, blood sugar and serum iron levels need to be monitored carefully and iron overdose should be prevented in these patients. |
| first_indexed | 2024-04-11T07:23:52Z |
| format | Article |
| id | doaj.art-0532d9d3401d46e0b6a04d030ae3bd1d |
| institution | Directory Open Access Journal |
| issn | 2345-4202 |
| language | English |
| last_indexed | 2024-04-11T07:23:52Z |
| publishDate | 2022-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropharmacology |
| spelling | doaj.art-0532d9d3401d46e0b6a04d030ae3bd1d2022-12-22T04:37:07ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropharmacology2345-42022022-07-01112e10489e1048910.34172/npj.2022.10489npj-10489Evaluating risk factors for catheter-related infections in hemodialysis patientsSepideh Hajian0Moosa Seifzade1Clinical Research Development Unit, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, IranQazvin University of Medical Sciences, Qazvin, IranIntroduction: Catheter-related infection in the patients with end-stage renal disease (ESRD) is one of the leading causes of death. Identifying risk factors for infection, including patients’ iron profile, plays an important role in preventing this complication. Objectives: In this study, we aimed to determine the risk factors of catheter-related infections among the ESRD patients in Qazvin, Iran. Patients and Methods: In this observational study, 41 patients with hemodialysis venous catheter-related infection (case group) and 42 patients without catheter-related infection ( control group) in Qazvin educational and medical centers were studied. The definition of functional iron deficiency anemia included ferritin <500 ng/mL and serum iron/total iron-binding capacity (TIBC) <30%. The laboratory evaluation method was based on enzyme-linked immunosorbent assay method. Definition of catheter-related infection in this study consisted of two positive results of the three cultures from blue and red catheter lines and blood at the same time with the same microorganism. Results: In studying iron parameters, a significant difference between serum iron levels and transferrin saturation in the two groups was detected (P values of 0.0016 and 0.003, respectively). Both parameters were higher in the control group. The most common microorganism causing the infection was Staphylococcus aureus (43.9%) and most of the catheters used were of temporary internal jugular vein types. The most important risk factors in the incidence of catheter infection were diabetes mellitus (OR = 5.059) and high serum iron levels (OR = 1.053). Decreased transferrin saturation levels reduced the risk of infection (OR = 0.825). Conclusion: There was a relationship between iron profile and diabetes mellitus and the increased risk of catheter-related infections. To prevent infection, patients with ESRD undergoing hemodialysis with venous catheters, blood sugar and serum iron levels need to be monitored carefully and iron overdose should be prevented in these patients.https://jnephropharmacology.com/PDF/npj-11-e10489.pdfcatheter-related infectionend-stage kidney diseasehemodialysisironferritin |
| spellingShingle | Sepideh Hajian Moosa Seifzade Evaluating risk factors for catheter-related infections in hemodialysis patients Journal of Nephropharmacology catheter-related infection end-stage kidney disease hemodialysis iron ferritin |
| title | Evaluating risk factors for catheter-related infections in hemodialysis patients |
| title_full | Evaluating risk factors for catheter-related infections in hemodialysis patients |
| title_fullStr | Evaluating risk factors for catheter-related infections in hemodialysis patients |
| title_full_unstemmed | Evaluating risk factors for catheter-related infections in hemodialysis patients |
| title_short | Evaluating risk factors for catheter-related infections in hemodialysis patients |
| title_sort | evaluating risk factors for catheter related infections in hemodialysis patients |
| topic | catheter-related infection end-stage kidney disease hemodialysis iron ferritin |
| url | https://jnephropharmacology.com/PDF/npj-11-e10489.pdf |
| work_keys_str_mv | AT sepidehhajian evaluatingriskfactorsforcatheterrelatedinfectionsinhemodialysispatients AT moosaseifzade evaluatingriskfactorsforcatheterrelatedinfectionsinhemodialysispatients |