Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients.
<h4>Background</h4>The role of interferon gamma (IFN-γ) expression in long-term survival has not been studied in patients with urinary bladder cancer (UBC). IFN-γ expression was characterized among various UBC patient cohorts to assess if IFN-γ status is associated with overall survival...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0271339 |
| _version_ | 1798003324425863168 |
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| author | Christina Gillezeau Naimisha Movva Maaike van Gerwen Karma Rabon-Stith Norah Shire Philip Zachary Brohawn Emanuela Taioli Jon Fryzek |
| author_facet | Christina Gillezeau Naimisha Movva Maaike van Gerwen Karma Rabon-Stith Norah Shire Philip Zachary Brohawn Emanuela Taioli Jon Fryzek |
| author_sort | Christina Gillezeau |
| collection | DOAJ |
| description | <h4>Background</h4>The role of interferon gamma (IFN-γ) expression in long-term survival has not been studied in patients with urinary bladder cancer (UBC). IFN-γ expression was characterized among various UBC patient cohorts to assess if IFN-γ status is associated with overall survival (OS).<h4>Methods</h4>A tumor-based IFN-γ gene signature was evaluated among adult UBC patients newly diagnosed between 2004 and 2017 from two hospital systems in New York. Patient cohorts included metastatic (stage IV or progressing to stage IV [MBC]), muscle-invasive (stages T2a to T4a [MIBC]), and non-muscle-invasive (carcinoma in situ or stages 0a, 0is, and I [NMIBC]) disease. Descriptive analyses were conducted comparing IFN-γ signature in the highest tertile to those in the lowest two tertiles.<h4>Results</h4>234 patients with bladder cancer were evaluated (56 MBC, 38 MIBC, and 140 NMIBC). Median OS was only reached in the MIBC cohort for those with an IFN-γ signature in the lowest two tertiles (15.03 months [95% CI, 8.50-50.60]). Those with an IFN-γ signature in the highest tertile had a decreased risk of mortality in all cohorts indicating better survival, but this was statistically significant in only the MIBC cohort (adjusted HR = 0.09 [95% CI, 0.01-0.73]).<h4>Conclusion</h4>IFN-γ signature status was associated with a decreased mortality risk in all cohorts, particularly MIBC, indicating that it may be a prognostic marker of survival in patients with UBC. |
| first_indexed | 2024-04-11T12:05:49Z |
| format | Article |
| id | doaj.art-0533594c0eac4d429089524b7bb7541b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T12:05:49Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0533594c0eac4d429089524b7bb7541b2022-12-22T04:24:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027133910.1371/journal.pone.0271339Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients.Christina GillezeauNaimisha MovvaMaaike van GerwenKarma Rabon-StithNorah ShirePhilip Zachary BrohawnEmanuela TaioliJon Fryzek<h4>Background</h4>The role of interferon gamma (IFN-γ) expression in long-term survival has not been studied in patients with urinary bladder cancer (UBC). IFN-γ expression was characterized among various UBC patient cohorts to assess if IFN-γ status is associated with overall survival (OS).<h4>Methods</h4>A tumor-based IFN-γ gene signature was evaluated among adult UBC patients newly diagnosed between 2004 and 2017 from two hospital systems in New York. Patient cohorts included metastatic (stage IV or progressing to stage IV [MBC]), muscle-invasive (stages T2a to T4a [MIBC]), and non-muscle-invasive (carcinoma in situ or stages 0a, 0is, and I [NMIBC]) disease. Descriptive analyses were conducted comparing IFN-γ signature in the highest tertile to those in the lowest two tertiles.<h4>Results</h4>234 patients with bladder cancer were evaluated (56 MBC, 38 MIBC, and 140 NMIBC). Median OS was only reached in the MIBC cohort for those with an IFN-γ signature in the lowest two tertiles (15.03 months [95% CI, 8.50-50.60]). Those with an IFN-γ signature in the highest tertile had a decreased risk of mortality in all cohorts indicating better survival, but this was statistically significant in only the MIBC cohort (adjusted HR = 0.09 [95% CI, 0.01-0.73]).<h4>Conclusion</h4>IFN-γ signature status was associated with a decreased mortality risk in all cohorts, particularly MIBC, indicating that it may be a prognostic marker of survival in patients with UBC.https://doi.org/10.1371/journal.pone.0271339 |
| spellingShingle | Christina Gillezeau Naimisha Movva Maaike van Gerwen Karma Rabon-Stith Norah Shire Philip Zachary Brohawn Emanuela Taioli Jon Fryzek Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. PLoS ONE |
| title | Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. |
| title_full | Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. |
| title_fullStr | Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. |
| title_full_unstemmed | Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. |
| title_short | Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients. |
| title_sort | interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients |
| url | https://doi.org/10.1371/journal.pone.0271339 |
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