Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview
Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative appr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1111963/full |
| _version_ | 1811155395700326400 |
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| author | Yanbei Wang Liping Liu Xinchuan Zheng Xin Liu |
| author_facet | Yanbei Wang Liping Liu Xinchuan Zheng Xin Liu |
| author_sort | Yanbei Wang |
| collection | DOAJ |
| description | Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative approaches to rebalancing the host immunity. In particular, the technique of membrane-coating has demonstrated remarkable improvements to therapeutic nanoparticles (NPs) in terms of tolerance and stability while also improving their biomimetic performance for immunomodulatory purposes. This development has led to the emergence of using cell-membrane-based biomimetic NPs in treating sepsis-associated immunologic derangements. In this minireview, we present an overview of the recent advances in membrane-camouflaged biomimetic NPs, highlighting their multifaceted immunomodulatory effects in sepsis such as anti-infection, vaccination, inflammation control, reversing of immunosuppression, and targeted delivery of immunomodulatory agents. |
| first_indexed | 2024-04-10T04:33:31Z |
| format | Article |
| id | doaj.art-0536a6719fa449d6916e59a778ff2e11 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T04:33:31Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-0536a6719fa449d6916e59a778ff2e112023-03-10T05:05:57ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11119631111963Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overviewYanbei Wang0Liping Liu1Xinchuan Zheng2Xin Liu3School of Culture and Tourism, Chongqing City Management College, Chongqing, ChinaSchool of Culture and Tourism, Chongqing City Management College, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaMedical Research Center, Southwest Hospital, Army Military Medical University, Chongqing, ChinaSepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative approaches to rebalancing the host immunity. In particular, the technique of membrane-coating has demonstrated remarkable improvements to therapeutic nanoparticles (NPs) in terms of tolerance and stability while also improving their biomimetic performance for immunomodulatory purposes. This development has led to the emergence of using cell-membrane-based biomimetic NPs in treating sepsis-associated immunologic derangements. In this minireview, we present an overview of the recent advances in membrane-camouflaged biomimetic NPs, highlighting their multifaceted immunomodulatory effects in sepsis such as anti-infection, vaccination, inflammation control, reversing of immunosuppression, and targeted delivery of immunomodulatory agents.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1111963/fullbiomimetic nanoparticlesmembrane-coatingsepsisinfectioninflammationimmunosuppression |
| spellingShingle | Yanbei Wang Liping Liu Xinchuan Zheng Xin Liu Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview Frontiers in Bioengineering and Biotechnology biomimetic nanoparticles membrane-coating sepsis infection inflammation immunosuppression |
| title | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
| title_full | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
| title_fullStr | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
| title_full_unstemmed | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
| title_short | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
| title_sort | membrane camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis an overview |
| topic | biomimetic nanoparticles membrane-coating sepsis infection inflammation immunosuppression |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1111963/full |
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