Cannabis and Inflammation in HIV: A Review of Human and Animal Studies
Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to character...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/8/1521 |
| _version_ | 1797521834280747008 |
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| author | Ronald J. Ellis Natalie Wilson Scott Peterson |
| author_facet | Ronald J. Ellis Natalie Wilson Scott Peterson |
| author_sort | Ronald J. Ellis |
| collection | DOAJ |
| description | Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to characterize the impact of cannabis use on inflammation specifically in PWH. We performed a selective, non-exhaustive review of the literature on the effects of cannabis on inflammation in PWH. Research in this area suggests that cannabinoids are anti-inflammatory in the setting of HIV. Anti-inflammatory actions are mediated in many cases through effects on the endocannabinoid system (ECS) in the gut, and through stabilization of gut–blood barrier integrity. Cannabidiol may be particularly important as an anti-inflammatory cannabinoid. Cannabis may provide a beneficial intervention to reduce morbidity related to inflammation in PWH. |
| first_indexed | 2024-03-10T08:18:09Z |
| format | Article |
| id | doaj.art-053768adb3b642e5ba346a840f9078b5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T08:18:09Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-053768adb3b642e5ba346a840f9078b52023-11-22T10:10:39ZengMDPI AGViruses1999-49152021-08-01138152110.3390/v13081521Cannabis and Inflammation in HIV: A Review of Human and Animal StudiesRonald J. Ellis0Natalie Wilson1Scott Peterson2Departments of Neurosciences and Psychiatry, University of California, San Diego, UCSD HNRC, Mail Code 8231 220 Dickinson Street, Suite B, San Diego, CA 92103, USADepartment of Community Health Systems, School of Nursing, University of California, San Francisco, 1700 Owens Street, Suite 316, San Francisco, CA 94158, USASanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USAPersistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to characterize the impact of cannabis use on inflammation specifically in PWH. We performed a selective, non-exhaustive review of the literature on the effects of cannabis on inflammation in PWH. Research in this area suggests that cannabinoids are anti-inflammatory in the setting of HIV. Anti-inflammatory actions are mediated in many cases through effects on the endocannabinoid system (ECS) in the gut, and through stabilization of gut–blood barrier integrity. Cannabidiol may be particularly important as an anti-inflammatory cannabinoid. Cannabis may provide a beneficial intervention to reduce morbidity related to inflammation in PWH.https://www.mdpi.com/1999-4915/13/8/1521cannabisinflammationHIVendocannabinoid systemgut microbiotagut barrier integrity |
| spellingShingle | Ronald J. Ellis Natalie Wilson Scott Peterson Cannabis and Inflammation in HIV: A Review of Human and Animal Studies Viruses cannabis inflammation HIV endocannabinoid system gut microbiota gut barrier integrity |
| title | Cannabis and Inflammation in HIV: A Review of Human and Animal Studies |
| title_full | Cannabis and Inflammation in HIV: A Review of Human and Animal Studies |
| title_fullStr | Cannabis and Inflammation in HIV: A Review of Human and Animal Studies |
| title_full_unstemmed | Cannabis and Inflammation in HIV: A Review of Human and Animal Studies |
| title_short | Cannabis and Inflammation in HIV: A Review of Human and Animal Studies |
| title_sort | cannabis and inflammation in hiv a review of human and animal studies |
| topic | cannabis inflammation HIV endocannabinoid system gut microbiota gut barrier integrity |
| url | https://www.mdpi.com/1999-4915/13/8/1521 |
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