In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA
Bloodstream infections by bacteria, especially multidrug-resistant bacteria, remain a worldwide public health concern. We evaluated the antibacterial activity of ceftobiprole and comparable drugs against different bloodstream isolates and different sequence types of methicillin-resistant <i>St...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/2/165 |
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| author | Lingqin Li Wangxiao Zhou Yunbo Chen Ping Shen Yonghong Xiao |
| author_facet | Lingqin Li Wangxiao Zhou Yunbo Chen Ping Shen Yonghong Xiao |
| author_sort | Lingqin Li |
| collection | DOAJ |
| description | Bloodstream infections by bacteria, especially multidrug-resistant bacteria, remain a worldwide public health concern. We evaluated the antibacterial activity of ceftobiprole and comparable drugs against different bloodstream isolates and different sequence types of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in China. We found that MRSA, methicillin-susceptible <i>Staphylococcus aureus</i> (MSSA), and methicillin-susceptible coagulase-negative <i>Staphylococcus</i> (MSCNS) displayed ceftobiprole sensitivity rates of >95%, which are similar to the rates for linezolid, daptomycin, and vancomycin. Of the tested MRCNS strains, 90.4% were sensitive to ceftobiprole. The sensitivities of ST59, ST398, and ST22 MRSA to ceftobiprole were higher than that of ST239. Ceftobiprole’s MIC<sub>50/90</sub> value against <i>Enterococcus faecalis</i> was 0.25/2 mg/L, whereas <i>Enterococcus faecium</i> was completely resistant to this drug. Ceftobiprole exhibited no activity against ESBL-positive Enterobacterales, with resistance rates between 78.6% and 100%. For ESBL-negative <i>Enterobacterales</i>, excluding <i>Klebsiella oxytoca</i>, the sensitivity to ceftobiprole was comparable to that of ceftazidime, ceftriaxone, and cefepime. The MIC<sub>50/90</sub> value of ceftobiprole against <i>Pseudomonas aeruginosa</i> was 2/16 mg/L, and for <i>Acinetobacter baumannii</i>, it was 32/>32 mg/L. Thus, ceftobiprole shows excellent antimicrobial activity against ESBL-negative <i>Enterobacterales</i> and <i>Pseudomonas aeruginosa</i> (comparable to that of ceftazidime, ceftriaxone, and cefepime); however, it is not effective against ESBL-positive <i>Enterobacterales</i> and <i>Acinetobacter baumannii</i>. These results provide important information to clinicians. |
| first_indexed | 2024-03-07T22:44:10Z |
| format | Article |
| id | doaj.art-05396b5ffa144834b946d3e1bd235cad |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-07T22:44:10Z |
| publishDate | 2024-02-01 |
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| series | Antibiotics |
| spelling | doaj.art-05396b5ffa144834b946d3e1bd235cad2024-02-23T15:05:07ZengMDPI AGAntibiotics2079-63822024-02-0113216510.3390/antibiotics13020165In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSALingqin Li0Wangxiao Zhou1Yunbo Chen2Ping Shen3Yonghong Xiao4State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBloodstream infections by bacteria, especially multidrug-resistant bacteria, remain a worldwide public health concern. We evaluated the antibacterial activity of ceftobiprole and comparable drugs against different bloodstream isolates and different sequence types of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in China. We found that MRSA, methicillin-susceptible <i>Staphylococcus aureus</i> (MSSA), and methicillin-susceptible coagulase-negative <i>Staphylococcus</i> (MSCNS) displayed ceftobiprole sensitivity rates of >95%, which are similar to the rates for linezolid, daptomycin, and vancomycin. Of the tested MRCNS strains, 90.4% were sensitive to ceftobiprole. The sensitivities of ST59, ST398, and ST22 MRSA to ceftobiprole were higher than that of ST239. Ceftobiprole’s MIC<sub>50/90</sub> value against <i>Enterococcus faecalis</i> was 0.25/2 mg/L, whereas <i>Enterococcus faecium</i> was completely resistant to this drug. Ceftobiprole exhibited no activity against ESBL-positive Enterobacterales, with resistance rates between 78.6% and 100%. For ESBL-negative <i>Enterobacterales</i>, excluding <i>Klebsiella oxytoca</i>, the sensitivity to ceftobiprole was comparable to that of ceftazidime, ceftriaxone, and cefepime. The MIC<sub>50/90</sub> value of ceftobiprole against <i>Pseudomonas aeruginosa</i> was 2/16 mg/L, and for <i>Acinetobacter baumannii</i>, it was 32/>32 mg/L. Thus, ceftobiprole shows excellent antimicrobial activity against ESBL-negative <i>Enterobacterales</i> and <i>Pseudomonas aeruginosa</i> (comparable to that of ceftazidime, ceftriaxone, and cefepime); however, it is not effective against ESBL-positive <i>Enterobacterales</i> and <i>Acinetobacter baumannii</i>. These results provide important information to clinicians.https://www.mdpi.com/2079-6382/13/2/165ceftobiproleminimum inhibitory concentrationbloodstream isolatesMRSAin vitro activity |
| spellingShingle | Lingqin Li Wangxiao Zhou Yunbo Chen Ping Shen Yonghong Xiao In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA Antibiotics ceftobiprole minimum inhibitory concentration bloodstream isolates MRSA in vitro activity |
| title | In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA |
| title_full | In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA |
| title_fullStr | In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA |
| title_full_unstemmed | In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA |
| title_short | In Vitro Antibacterial Activity of Ceftobiprole and Comparator Compounds against Nation-Wide Bloodstream Isolates and Different Sequence Types of MRSA |
| title_sort | in vitro antibacterial activity of ceftobiprole and comparator compounds against nation wide bloodstream isolates and different sequence types of mrsa |
| topic | ceftobiprole minimum inhibitory concentration bloodstream isolates MRSA in vitro activity |
| url | https://www.mdpi.com/2079-6382/13/2/165 |
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