Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits
Abstract Intravascular photoacoustic (IVPA) imaging is a promising modality for quantitative assessment of lipid‐laden atherosclerotic plaques. Yet, survival IVPA imaging of the same plaque in the same animal is not demonstrated. Here, using a sheathed IVUS/PA catheter of 0.9 mm in diameter, we demo...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
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Wiley-VCH
2022-12-01
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Series: | Translational Biophotonics |
Subjects: | |
Online Access: | https://doi.org/10.1002/tbio.202200012 |
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author | Yi Zhang Erik Taylor Nasi Huang James Hamilton Ji‐Xin Cheng |
author_facet | Yi Zhang Erik Taylor Nasi Huang James Hamilton Ji‐Xin Cheng |
author_sort | Yi Zhang |
collection | DOAJ |
description | Abstract Intravascular photoacoustic (IVPA) imaging is a promising modality for quantitative assessment of lipid‐laden atherosclerotic plaques. Yet, survival IVPA imaging of the same plaque in the same animal is not demonstrated. Here, using a sheathed IVUS/PA catheter of 0.9 mm in diameter, we demonstrate MRI‐guided survival IVPA imaging of same plaque in an aorta of a well‐established rabbit model mimicking atherosclerosis in human patients. The IVUS/PA results were confirmed by histology. These advances open the opportunity to evaluate the effectiveness of a therapy that aims to reduce the size of atherosclerotic plaques and demonstrates the potential of translating the IVPA catheter into clinic for detection of lipid‐rich plaques that are at high risk for thrombosis. |
first_indexed | 2024-04-11T04:46:14Z |
format | Article |
id | doaj.art-053981fbf7774172b11c12ebbd90568f |
institution | Directory Open Access Journal |
issn | 2627-1850 |
language | English |
last_indexed | 2024-04-11T04:46:14Z |
publishDate | 2022-12-01 |
publisher | Wiley-VCH |
record_format | Article |
series | Translational Biophotonics |
spelling | doaj.art-053981fbf7774172b11c12ebbd90568f2022-12-27T11:24:06ZengWiley-VCHTranslational Biophotonics2627-18502022-12-0144n/an/a10.1002/tbio.202200012Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbitsYi Zhang0Erik Taylor1Nasi Huang2James Hamilton3Ji‐Xin Cheng4Department of Physics Boston University Boston Massachusetts USADepartment of Physiology and Biophysics Boston University School of Medicine Boston Massachusetts USADepartment of Physiology and Biophysics Boston University School of Medicine Boston Massachusetts USADepartment of Physiology and Biophysics Boston University School of Medicine Boston Massachusetts USADepartment of Physics Boston University Boston Massachusetts USAAbstract Intravascular photoacoustic (IVPA) imaging is a promising modality for quantitative assessment of lipid‐laden atherosclerotic plaques. Yet, survival IVPA imaging of the same plaque in the same animal is not demonstrated. Here, using a sheathed IVUS/PA catheter of 0.9 mm in diameter, we demonstrate MRI‐guided survival IVPA imaging of same plaque in an aorta of a well‐established rabbit model mimicking atherosclerosis in human patients. The IVUS/PA results were confirmed by histology. These advances open the opportunity to evaluate the effectiveness of a therapy that aims to reduce the size of atherosclerotic plaques and demonstrates the potential of translating the IVPA catheter into clinic for detection of lipid‐rich plaques that are at high risk for thrombosis.https://doi.org/10.1002/tbio.202200012atherosclerosisintravascularphoto acousticsurvival |
spellingShingle | Yi Zhang Erik Taylor Nasi Huang James Hamilton Ji‐Xin Cheng Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits Translational Biophotonics atherosclerosis intravascular photo acoustic survival |
title | Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits |
title_full | Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits |
title_fullStr | Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits |
title_full_unstemmed | Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits |
title_short | Survival intravascular photoacoustic imaging of lipid‐rich plaque in cholesterol fed rabbits |
title_sort | survival intravascular photoacoustic imaging of lipid rich plaque in cholesterol fed rabbits |
topic | atherosclerosis intravascular photo acoustic survival |
url | https://doi.org/10.1002/tbio.202200012 |
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