Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer

Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer

Abstract Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show that the breast tumor suppressor gene SIM2 promotes mitochondrial oxidative phosphorylation (OXPHOS) using breast cancer cell line mode...

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Bibliographic Details
Main Authors: Steven W. Wall, Lilia Sanchez, Kelly Scribner Tuttle, Scott J. Pearson, Shivatheja Soma, Garhett L. Wyatt, Hannah N. Carter, Ramsey M. Jenschke, Lin Tan, Sara A. Martinez, Philip L. Lorenzi, Vishal M. Gohil, Monique Rijnkels, Weston W. Porter
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-00996-0

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