Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study
Introduction Epigenetics hypothesizes a crucial link between postnatal risk factors, individual response to stress, DNA methylation and psychiatric symptomatology changes during life. Objectives We analyzed methylation within two gene exons: NR3C1 and SLC6A4, which are involved in responses to e...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821003473/type/journal_article |
| _version_ | 1797616899638427648 |
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| author | F. Villa E. Rosi S. Grazioli M. Mauri R. Giorda P. Brambilla C. Bonivento M. Garzitto M. Molteni M. Nobile |
| author_facet | F. Villa E. Rosi S. Grazioli M. Mauri R. Giorda P. Brambilla C. Bonivento M. Garzitto M. Molteni M. Nobile |
| author_sort | F. Villa |
| collection | DOAJ |
| description |
Introduction
Epigenetics hypothesizes a crucial link between postnatal risk factors, individual response to stress, DNA methylation and psychiatric symptomatology changes during life.
Objectives
We analyzed methylation within two gene exons: NR3C1 and SLC6A4, which are involved in responses to environmental stressors. We investigated the relationship between methylation, postnatal risk factors and psychopathology assessed by Child Behavior Checklist (CBCL) in our help-seeking sample evaluated in infancy (W1), preadolescence (W2) and adult life (W3).
Methods
Postnatal risk factors data were collected at W1 in 205 clinical subjects (156 M, 49 F; age=9,13±1,95). The CBCL scores were collected at W1 and W2 (W2 age=14,52±2,12). Data regarding methylation were collected at W2. At W3 we are also collecting clinical scores. A Spearman correlation coefficient was calculated between methylation percentage and clinical data at W2. The externalizing and internalizing trajectories were evaluated through repeated measure ANOVA with postnatal risk factors (presence/absence) as between-groups factor.
Results
Significant associations were found between methylation and internalizing and total clinical scores (Table 1). The rm-ANOVA results showed a significant interaction between the CBCL internalizing score and presence/absence of postnatal risk, with higher internalizing problems in subjects that were exposed to postnatal risk factors. This effect was significant at W2 but not at W1 (Figure 1).
Conclusions
Psychopathological symptoms trajectories could depend on epigenetics and early environmental risk factors. Further analyses will address a Linear Discriminant Analysis to proceed to a machine learning oriented approach.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:47:52Z |
| format | Article |
| id | doaj.art-053de224e4484418913bef2935829b6c |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:47:52Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-053de224e4484418913bef2935829b6c2023-11-17T05:07:12ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S123S12410.1192/j.eurpsy.2021.347Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal studyF. Villa0E. Rosi1S. Grazioli2M. Mauri3R. Giorda4P. Brambilla5C. Bonivento6M. Garzitto7M. Molteni8M. Nobile9Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, ItalyDevelopmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, ItalyDevelopmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, ItalyDevelopmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, ItalyMolecular Biology Laboratory, Scientific Institute, IRCCS E. Medea, Bosisio Parini, ItalyDepartment Of Pathophysiology And Transplantation, University of Milan, Milan, ItalyAssociazione La Nostra Famiglia, Scientific Institute, IRCCS E. Medea, Pasian di Prato, ItalyAssociazione La Nostra Famiglia, Scientific Institute, IRCCS E. Medea, Pasian di Prato, ItalyDevelopmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, ItalyChild And Adolescent Psychiatry Unit, Scientific Institute IRCCS ‘E. Medea?, Bosisio Parini, Italy Introduction Epigenetics hypothesizes a crucial link between postnatal risk factors, individual response to stress, DNA methylation and psychiatric symptomatology changes during life. Objectives We analyzed methylation within two gene exons: NR3C1 and SLC6A4, which are involved in responses to environmental stressors. We investigated the relationship between methylation, postnatal risk factors and psychopathology assessed by Child Behavior Checklist (CBCL) in our help-seeking sample evaluated in infancy (W1), preadolescence (W2) and adult life (W3). Methods Postnatal risk factors data were collected at W1 in 205 clinical subjects (156 M, 49 F; age=9,13±1,95). The CBCL scores were collected at W1 and W2 (W2 age=14,52±2,12). Data regarding methylation were collected at W2. At W3 we are also collecting clinical scores. A Spearman correlation coefficient was calculated between methylation percentage and clinical data at W2. The externalizing and internalizing trajectories were evaluated through repeated measure ANOVA with postnatal risk factors (presence/absence) as between-groups factor. Results Significant associations were found between methylation and internalizing and total clinical scores (Table 1). The rm-ANOVA results showed a significant interaction between the CBCL internalizing score and presence/absence of postnatal risk, with higher internalizing problems in subjects that were exposed to postnatal risk factors. This effect was significant at W2 but not at W1 (Figure 1). Conclusions Psychopathological symptoms trajectories could depend on epigenetics and early environmental risk factors. Further analyses will address a Linear Discriminant Analysis to proceed to a machine learning oriented approach. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821003473/type/journal_articlemethylationepigeneticspostnatal risk factorspsychopathology trajectories |
| spellingShingle | F. Villa E. Rosi S. Grazioli M. Mauri R. Giorda P. Brambilla C. Bonivento M. Garzitto M. Molteni M. Nobile Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study European Psychiatry methylation epigenetics postnatal risk factors psychopathology trajectories |
| title | Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study |
| title_full | Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study |
| title_fullStr | Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study |
| title_full_unstemmed | Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study |
| title_short | Associations between genes methylation, postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents: Preliminar results from the remind longitudinal study |
| title_sort | associations between genes methylation postnatal risk factors and psychiatric symptoms in a clinical sample of children and adolescents preliminar results from the remind longitudinal study |
| topic | methylation epigenetics postnatal risk factors psychopathology trajectories |
| url | https://www.cambridge.org/core/product/identifier/S0924933821003473/type/journal_article |
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