Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention
The regulatory and functional roles of non-coding RNAs are increasingly demonstrated as critical in cancer. Among non-coding RNAs, microRNAs (miRNAs) are the most well-studied with direct regulation of biological signals through post-transcriptional repression of mRNAs. Like the transcriptome, which...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/3/651 |
| _version_ | 1797472654975827968 |
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| author | Raj Pranap Arun Hannah F. Cahill Paola Marcato |
| author_facet | Raj Pranap Arun Hannah F. Cahill Paola Marcato |
| author_sort | Raj Pranap Arun |
| collection | DOAJ |
| description | The regulatory and functional roles of non-coding RNAs are increasingly demonstrated as critical in cancer. Among non-coding RNAs, microRNAs (miRNAs) are the most well-studied with direct regulation of biological signals through post-transcriptional repression of mRNAs. Like the transcriptome, which varies between tissue type and disease condition, the miRNA landscape is also similarly altered and shows disease-specific changes. The importance of individual tumor-promoting or suppressing miRNAs is well documented in breast cancer; however, the implications of miRNA networks is less defined. Some evidence suggests that breast cancer subtype-specific cellular effects are influenced by distinct miRNAs and a comprehensive network of subtype-specific miRNAs and mRNAs would allow us to better understand breast cancer signaling. In this review, we discuss the altered miRNA landscape in the context of breast cancer and propose that breast cancer subtypes have distinct miRNA dysregulation. Further, given that miRNAs can be used as diagnostic and/or prognostic biomarkers, their impact as novel targets for subtype-specific therapy is also possible and suggest important implications for subtype-specific miRNAs. |
| first_indexed | 2024-03-09T20:05:25Z |
| format | Article |
| id | doaj.art-05438e5e17b84a849a2d4172e6cb2dce |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-05438e5e17b84a849a2d4172e6cb2dce2023-11-24T00:33:20ZengMDPI AGBiomedicines2227-90592022-03-0110365110.3390/biomedicines10030651Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for InterventionRaj Pranap Arun0Hannah F. Cahill1Paola Marcato2Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Pathology, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Pathology, Dalhousie University, Halifax, NS B3H 4R2, CanadaThe regulatory and functional roles of non-coding RNAs are increasingly demonstrated as critical in cancer. Among non-coding RNAs, microRNAs (miRNAs) are the most well-studied with direct regulation of biological signals through post-transcriptional repression of mRNAs. Like the transcriptome, which varies between tissue type and disease condition, the miRNA landscape is also similarly altered and shows disease-specific changes. The importance of individual tumor-promoting or suppressing miRNAs is well documented in breast cancer; however, the implications of miRNA networks is less defined. Some evidence suggests that breast cancer subtype-specific cellular effects are influenced by distinct miRNAs and a comprehensive network of subtype-specific miRNAs and mRNAs would allow us to better understand breast cancer signaling. In this review, we discuss the altered miRNA landscape in the context of breast cancer and propose that breast cancer subtypes have distinct miRNA dysregulation. Further, given that miRNAs can be used as diagnostic and/or prognostic biomarkers, their impact as novel targets for subtype-specific therapy is also possible and suggest important implications for subtype-specific miRNAs.https://www.mdpi.com/2227-9059/10/3/651microRNA (miRNA)breast cancersubtype specificitytriple negative breast cancer (TNBC)human epidermal growth factor receptor 2 (HER2)estrogen receptor (ER) |
| spellingShingle | Raj Pranap Arun Hannah F. Cahill Paola Marcato Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention Biomedicines microRNA (miRNA) breast cancer subtype specificity triple negative breast cancer (TNBC) human epidermal growth factor receptor 2 (HER2) estrogen receptor (ER) |
| title | Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention |
| title_full | Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention |
| title_fullStr | Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention |
| title_full_unstemmed | Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention |
| title_short | Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention |
| title_sort | breast cancer subtype specific mirnas networks impacts and the potential for intervention |
| topic | microRNA (miRNA) breast cancer subtype specificity triple negative breast cancer (TNBC) human epidermal growth factor receptor 2 (HER2) estrogen receptor (ER) |
| url | https://www.mdpi.com/2227-9059/10/3/651 |
| work_keys_str_mv | AT rajpranaparun breastcancersubtypespecificmirnasnetworksimpactsandthepotentialforintervention AT hannahfcahill breastcancersubtypespecificmirnasnetworksimpactsandthepotentialforintervention AT paolamarcato breastcancersubtypespecificmirnasnetworksimpactsandthepotentialforintervention |