Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression
Atrial fibrillation (AF) is a common arrhythmia in clinical practice, and its incidence is increasing year by year, which seriously affects the survival and prognosis of patients. In recent years, circRNAs has played an important role in the diagnosis and treatment of AF. The purpose of this study w...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580823001589 |
| _version_ | 1827609470078812160 |
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| author | Zongqian Xue Jinbiao Zhu Juan Liu Lingli Wang Jijun Ding |
| author_facet | Zongqian Xue Jinbiao Zhu Juan Liu Lingli Wang Jijun Ding |
| author_sort | Zongqian Xue |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is a common arrhythmia in clinical practice, and its incidence is increasing year by year, which seriously affects the survival and prognosis of patients. In recent years, circRNAs has played an important role in the diagnosis and treatment of AF. The purpose of this study was to search for differentially expressed circRNAs(DEcircRNAs) in the serum of AF patients by analyzing the expression profile of existing chips, combining bioinformatics technology and in vitro experiments, and to explore the regulatory mechanism of circRNAs in the occurrence and development of AF. By using the AF datasets in the Gene expression omnibus (GEO) database, serum samples of patients with AF were collected, and the expression level of selected circRNAs was verified by qPCR. We found that the expression of four circRNAs was increased in the serum of patients with AF, suggesting that these four DEcircRNAs may be used as auxiliary diagnostic markers for AF. Bioinformatics predicts the related signaling pathways that differentially expressed genes may regulate in the occurrence and development of AF, providing a new theoretical basis for the molecular mechanism of the occurrence of atrial fibrillation and auxiliary diagnostic targets. |
| first_indexed | 2024-03-09T07:33:51Z |
| format | Article |
| id | doaj.art-0543e7ccd8d24b4dbb9b1ce31c1a0eec |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-09T07:33:51Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-0543e7ccd8d24b4dbb9b1ce31c1a0eec2023-12-03T05:41:59ZengElsevierBiochemistry and Biophysics Reports2405-58082023-12-0136101577Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expressionZongqian Xue0Jinbiao Zhu1Juan Liu2Lingli Wang3Jijun Ding4Department of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, 215600, ChinaDepartment of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, 215600, ChinaDepartment of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, 215600, ChinaDepartment of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, 215600, ChinaCorresponding author.; Department of Cardiology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang, 215600, ChinaAtrial fibrillation (AF) is a common arrhythmia in clinical practice, and its incidence is increasing year by year, which seriously affects the survival and prognosis of patients. In recent years, circRNAs has played an important role in the diagnosis and treatment of AF. The purpose of this study was to search for differentially expressed circRNAs(DEcircRNAs) in the serum of AF patients by analyzing the expression profile of existing chips, combining bioinformatics technology and in vitro experiments, and to explore the regulatory mechanism of circRNAs in the occurrence and development of AF. By using the AF datasets in the Gene expression omnibus (GEO) database, serum samples of patients with AF were collected, and the expression level of selected circRNAs was verified by qPCR. We found that the expression of four circRNAs was increased in the serum of patients with AF, suggesting that these four DEcircRNAs may be used as auxiliary diagnostic markers for AF. Bioinformatics predicts the related signaling pathways that differentially expressed genes may regulate in the occurrence and development of AF, providing a new theoretical basis for the molecular mechanism of the occurrence of atrial fibrillation and auxiliary diagnostic targets.http://www.sciencedirect.com/science/article/pii/S2405580823001589Atrial fibrillationcircRNAsBiomarkerDiagnosisceRNA |
| spellingShingle | Zongqian Xue Jinbiao Zhu Juan Liu Lingli Wang Jijun Ding Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression Biochemistry and Biophysics Reports Atrial fibrillation circRNAs Biomarker Diagnosis ceRNA |
| title | Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression |
| title_full | Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression |
| title_fullStr | Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression |
| title_full_unstemmed | Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression |
| title_short | Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression |
| title_sort | circular rnas in atrial fibrillation from bioinformatics analysis of circrna mirna mrna network to serum expression |
| topic | Atrial fibrillation circRNAs Biomarker Diagnosis ceRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2405580823001589 |
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