Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review
Sulfonamidochalcones continue to assert themselves as versatile synthetic intermedi-ates and several articles continue to appear in literature describing their synthesis, chemical transformation and biological properties. These compounds are not only of interest from the medicinal chemistry context,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/19/5923 |
| _version_ | 1797515897388138496 |
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| author | Malose J. Mphahlele |
| author_facet | Malose J. Mphahlele |
| author_sort | Malose J. Mphahlele |
| collection | DOAJ |
| description | Sulfonamidochalcones continue to assert themselves as versatile synthetic intermedi-ates and several articles continue to appear in literature describing their synthesis, chemical transformation and biological properties. These compounds are not only of interest from the medicinal chemistry context, their conformations and crystalline structures also continue to attract attention to explore non-covalent (intramolecular and intermolecular) interactions, control molecular conformations, and improve their physicochemical and optical properties. Despite an exhaustive list of examples of the ring-A sulfonamide-appended chalcones described in the literature, there is no com-prehensive review dedicated to their synthesis, structural and biological properties. This review focuses attention on the synthesis, structure and biological properties of the ring-A sulfonamide-appended chalcones (<i>o</i>/<i>m</i>/<i>p</i>-sulfonamidochalcones) as well as their potential as non-linear optical materials. |
| first_indexed | 2024-03-10T06:53:39Z |
| format | Article |
| id | doaj.art-054437a0e9f84f6aa47bbb5b6e4c58a2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:53:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-054437a0e9f84f6aa47bbb5b6e4c58a22023-11-22T16:34:40ZengMDPI AGMolecules1420-30492021-09-012619592310.3390/molecules26195923Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A ReviewMalose J. Mphahlele0Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South AfricaSulfonamidochalcones continue to assert themselves as versatile synthetic intermedi-ates and several articles continue to appear in literature describing their synthesis, chemical transformation and biological properties. These compounds are not only of interest from the medicinal chemistry context, their conformations and crystalline structures also continue to attract attention to explore non-covalent (intramolecular and intermolecular) interactions, control molecular conformations, and improve their physicochemical and optical properties. Despite an exhaustive list of examples of the ring-A sulfonamide-appended chalcones described in the literature, there is no com-prehensive review dedicated to their synthesis, structural and biological properties. This review focuses attention on the synthesis, structure and biological properties of the ring-A sulfonamide-appended chalcones (<i>o</i>/<i>m</i>/<i>p</i>-sulfonamidochalcones) as well as their potential as non-linear optical materials.https://www.mdpi.com/1420-3049/26/19/5923<i>o</i>/<i>m</i>/<i>p</i>-sulfonamidochalconesmolecular structurebiological activityoptical properties |
| spellingShingle | Malose J. Mphahlele Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review Molecules <i>o</i>/<i>m</i>/<i>p</i>-sulfonamidochalcones molecular structure biological activity optical properties |
| title | Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review |
| title_full | Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review |
| title_fullStr | Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review |
| title_full_unstemmed | Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review |
| title_short | Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review |
| title_sort | synthesis structural and biological properties of the ring a sulfonamido substituted chalcones a review |
| topic | <i>o</i>/<i>m</i>/<i>p</i>-sulfonamidochalcones molecular structure biological activity optical properties |
| url | https://www.mdpi.com/1420-3049/26/19/5923 |
| work_keys_str_mv | AT malosejmphahlele synthesisstructuralandbiologicalpropertiesoftheringasulfonamidosubstitutedchalconesareview |