The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study
Abstract Background Arterial hypertension, cigarette smoking, excessive alcohol abuse and drug addiction such as cocaine all are known risk factors for aneurysmal subarachnoid hemorrhage (SAH). However, there is little information on whether tramadol addiction should also be considered as a risk fac...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00703-w |
| _version_ | 1797778944140771328 |
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| author | Ahmed Elbassiony Eman M. Khedr Ahmed Hegazy Omar Abdelaleem Ragab Hieder Al-Shami Radwa K. Soliman Ahmed Shoyb Ahmed Aly |
| author_facet | Ahmed Elbassiony Eman M. Khedr Ahmed Hegazy Omar Abdelaleem Ragab Hieder Al-Shami Radwa K. Soliman Ahmed Shoyb Ahmed Aly |
| author_sort | Ahmed Elbassiony |
| collection | DOAJ |
| description | Abstract Background Arterial hypertension, cigarette smoking, excessive alcohol abuse and drug addiction such as cocaine all are known risk factors for aneurysmal subarachnoid hemorrhage (SAH). However, there is little information on whether tramadol addiction should also be considered as a risk factor for SAH. The purpose of this study was to investigate the prevalence and the impact of tramadol addiction on the symptomatology of intracranial aneurysmal SAH. We recruited 237 cases with acute aneurysmal ASH with a mean age of 52.3 ± 11.8 ranging from 17 to 86 years old. Results There were 124 males and 113 females; 43 cases had a history of tramadol addiction (18.1%). Tramadol addicts were significantly younger, more likely to be male (97.7%), and more commonly associated with seizure onset compared with non-addicts. Multiple aneurysms, wide neck, and sizable aneurysms were significantly more common in tramadol than non-tramadol addicts as were dissecting aneurysms. There is a high association of acute aneurysmal SAH with tramadol addiction, especially in young patients. Conclusions Tramadol addiction might be regarded as modifiable risk factor of aneurysmal ASH and tramadol addicts had a worse presentation than non-tramadol addicts. If this finding is proved, it will be of great importance in managing patients with ruptured and un-ruptured intracranial aneurysms. Tramadol is available over-counter in some countries, more studies are needed. |
| first_indexed | 2024-03-12T23:24:49Z |
| format | Article |
| id | doaj.art-0545aaaec16a42888873071baec03531 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-12T23:24:49Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-0545aaaec16a42888873071baec035312023-07-16T11:12:32ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-07-015911910.1186/s41983-023-00703-wThe frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter studyAhmed Elbassiony0Eman M. Khedr1Ahmed Hegazy2Omar Abdelaleem Ragab3Hieder Al-Shami4Radwa K. Soliman5Ahmed Shoyb6Ahmed Aly7Department of Neuropsychiatry, Faculty of Medicine, Ain Shams UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Assiut UniversityDepartment of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical CollegeDepartment of Neurosurgery, Faculty of Medicine, Beni Suef UniversityDepartment of Neurosurgery, Al-Azhar UniversityDepartment of Radiology, Faculty of Medicine, Assiut UniversityDepartment of Neuropsychiatry, Faculty of Medicine, Aswan UniversityDepartment of Neurosurgery, Faculty of Medicine, Aswan UniversityAbstract Background Arterial hypertension, cigarette smoking, excessive alcohol abuse and drug addiction such as cocaine all are known risk factors for aneurysmal subarachnoid hemorrhage (SAH). However, there is little information on whether tramadol addiction should also be considered as a risk factor for SAH. The purpose of this study was to investigate the prevalence and the impact of tramadol addiction on the symptomatology of intracranial aneurysmal SAH. We recruited 237 cases with acute aneurysmal ASH with a mean age of 52.3 ± 11.8 ranging from 17 to 86 years old. Results There were 124 males and 113 females; 43 cases had a history of tramadol addiction (18.1%). Tramadol addicts were significantly younger, more likely to be male (97.7%), and more commonly associated with seizure onset compared with non-addicts. Multiple aneurysms, wide neck, and sizable aneurysms were significantly more common in tramadol than non-tramadol addicts as were dissecting aneurysms. There is a high association of acute aneurysmal SAH with tramadol addiction, especially in young patients. Conclusions Tramadol addiction might be regarded as modifiable risk factor of aneurysmal ASH and tramadol addicts had a worse presentation than non-tramadol addicts. If this finding is proved, it will be of great importance in managing patients with ruptured and un-ruptured intracranial aneurysms. Tramadol is available over-counter in some countries, more studies are needed.https://doi.org/10.1186/s41983-023-00703-wAcute aneurysmal subarachnoid hemorrhageTramadol addictionHess and Hunt stagingRisk factorDrug addiction |
| spellingShingle | Ahmed Elbassiony Eman M. Khedr Ahmed Hegazy Omar Abdelaleem Ragab Hieder Al-Shami Radwa K. Soliman Ahmed Shoyb Ahmed Aly The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Acute aneurysmal subarachnoid hemorrhage Tramadol addiction Hess and Hunt staging Risk factor Drug addiction |
| title | The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study |
| title_full | The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study |
| title_fullStr | The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study |
| title_full_unstemmed | The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study |
| title_short | The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study |
| title_sort | frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage cross sectional multicenter study |
| topic | Acute aneurysmal subarachnoid hemorrhage Tramadol addiction Hess and Hunt staging Risk factor Drug addiction |
| url | https://doi.org/10.1186/s41983-023-00703-w |
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