Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is one of the most common and increasing liver diseases worldwide. NAFLD is a term that involves a variety of conditions such as fatty liver, steatohepatitis, or fibrosis. Gut microbiota and its products have been extensively studied because of a close relati...
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| Format: | Article |
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MDPI AG
2021-10-01
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| author | Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Yoseph Asmelash Gebru Raja Ganesan Haripriya Gupta Ki Tae Suk Dong Joon Kim |
| author_facet | Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Yoseph Asmelash Gebru Raja Ganesan Haripriya Gupta Ki Tae Suk Dong Joon Kim |
| author_sort | Eunju Park |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is one of the most common and increasing liver diseases worldwide. NAFLD is a term that involves a variety of conditions such as fatty liver, steatohepatitis, or fibrosis. Gut microbiota and its products have been extensively studied because of a close relation between NAFLD and microbiota in pathogenesis. In the progression of NAFLD, various microbiota-related molecular and cellular mechanisms, including dysbiosis, leaky bowel, endotoxin, bile acids enterohepatic circulation, metabolites, or alcohol-producing microbiota, are involved. Currently, diagnosis and treatment techniques using these mechanisms are being developed. In this review, we will introduce the microbiota-related mechanisms in the progression of NAFLD and future directions will be discussed. |
| first_indexed | 2024-03-10T06:39:08Z |
| format | Article |
| id | doaj.art-0545dc4cd9a14bb590f076144ded00ab |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:08Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0545dc4cd9a14bb590f076144ded00ab2023-11-22T17:46:44ZengMDPI AGCells2073-44092021-10-011010263410.3390/cells10102634Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver DiseaseEunju Park0Jin-Ju Jeong1Sung-Min Won2Satya Priya Sharma3Yoseph Asmelash Gebru4Raja Ganesan5Haripriya Gupta6Ki Tae Suk7Dong Joon Kim8Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, KoreaNonalcoholic fatty liver disease (NAFLD) is one of the most common and increasing liver diseases worldwide. NAFLD is a term that involves a variety of conditions such as fatty liver, steatohepatitis, or fibrosis. Gut microbiota and its products have been extensively studied because of a close relation between NAFLD and microbiota in pathogenesis. In the progression of NAFLD, various microbiota-related molecular and cellular mechanisms, including dysbiosis, leaky bowel, endotoxin, bile acids enterohepatic circulation, metabolites, or alcohol-producing microbiota, are involved. Currently, diagnosis and treatment techniques using these mechanisms are being developed. In this review, we will introduce the microbiota-related mechanisms in the progression of NAFLD and future directions will be discussed.https://www.mdpi.com/2073-4409/10/10/2634nonalcoholic fatty liver diseasegut microbiotadysbiosisgut microbial metabolites |
| spellingShingle | Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Yoseph Asmelash Gebru Raja Ganesan Haripriya Gupta Ki Tae Suk Dong Joon Kim Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease Cells nonalcoholic fatty liver disease gut microbiota dysbiosis gut microbial metabolites |
| title | Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease |
| title_full | Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease |
| title_fullStr | Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease |
| title_short | Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease |
| title_sort | gut microbiota related cellular and molecular mechanisms in the progression of nonalcoholic fatty liver disease |
| topic | nonalcoholic fatty liver disease gut microbiota dysbiosis gut microbial metabolites |
| url | https://www.mdpi.com/2073-4409/10/10/2634 |
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