The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy
A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resista...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1067974/full |
| _version_ | 1811175237817991168 |
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| author | Hendrik Setia Budi Laith A. Younus Methaq Hadi Lafta Sameena Parveen Hawraa Jabbar Mohammad Zahraa Haleem Al-qaim Mohammed Abed Jawad Rosario Mireya Romero Parra Yasser Fakri Mustafa Firas Rahi Alhachami Sajad Karampoor Rasoul Mirzaei |
| author_facet | Hendrik Setia Budi Laith A. Younus Methaq Hadi Lafta Sameena Parveen Hawraa Jabbar Mohammad Zahraa Haleem Al-qaim Mohammed Abed Jawad Rosario Mireya Romero Parra Yasser Fakri Mustafa Firas Rahi Alhachami Sajad Karampoor Rasoul Mirzaei |
| author_sort | Hendrik Setia Budi |
| collection | DOAJ |
| description | A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed. |
| first_indexed | 2024-04-10T19:34:01Z |
| format | Article |
| id | doaj.art-05479753d1dd4a0297f6154b9be759be |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T19:34:01Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-05479753d1dd4a0297f6154b9be759be2023-01-30T09:18:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10679741067974The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapyHendrik Setia Budi0Laith A. Younus1Methaq Hadi Lafta2Sameena Parveen3Hawraa Jabbar Mohammad4Zahraa Haleem Al-qaim5Mohammed Abed Jawad6Rosario Mireya Romero Parra7Yasser Fakri Mustafa8Firas Rahi Alhachami9Sajad Karampoor10Rasoul Mirzaei11Department of Oral Biology, Dental Pharmacology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Laboratory Sciences, Faculty of Pharmacy, Jabir Ibn, Hayyan Medical University, Al Najaf Al Ashraf, IraqIraqi Ministry of Education, Baghdad, IraqDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi ArabiaAl-Manara College For Medical Sciences, Maysan, IraqDepartment of Anesthesia Techniques , Al-Mustaqbal University College, Hilla, IraqAl-Nisour University College, Baghdad, IraqUniversidad Continental, Lima, PeruDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq0Radiology Department, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq1Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran2Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IranA growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.https://www.frontiersin.org/articles/10.3389/fonc.2022.1067974/fullmiR-128cancer progressioncancer suppressionchemoresistanceimmunotherapy |
| spellingShingle | Hendrik Setia Budi Laith A. Younus Methaq Hadi Lafta Sameena Parveen Hawraa Jabbar Mohammad Zahraa Haleem Al-qaim Mohammed Abed Jawad Rosario Mireya Romero Parra Yasser Fakri Mustafa Firas Rahi Alhachami Sajad Karampoor Rasoul Mirzaei The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy Frontiers in Oncology miR-128 cancer progression cancer suppression chemoresistance immunotherapy |
| title | The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy |
| title_full | The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy |
| title_fullStr | The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy |
| title_full_unstemmed | The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy |
| title_short | The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy |
| title_sort | role of mir 128 in cancer development prevention drug resistance and immunotherapy |
| topic | miR-128 cancer progression cancer suppression chemoresistance immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1067974/full |
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