Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive
The manipulation of autophagy for cancer therapy has gained recent interest in clinical settings. Although inhibition of autophagy is currently being used in clinical trials for the treatment of several malignancies, autophagy has been shown to have diverse implications for normal cell homeostasis,...
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MDPI AG
2019-09-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/8/4/71 |
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| author | Guadalupe Rojas-Sanchez Israel Cotzomi-Ortega Nidia G. Pazos-Salazar Julio Reyes-Leyva Paola Maycotte |
| author_facet | Guadalupe Rojas-Sanchez Israel Cotzomi-Ortega Nidia G. Pazos-Salazar Julio Reyes-Leyva Paola Maycotte |
| author_sort | Guadalupe Rojas-Sanchez |
| collection | DOAJ |
| description | The manipulation of autophagy for cancer therapy has gained recent interest in clinical settings. Although inhibition of autophagy is currently being used in clinical trials for the treatment of several malignancies, autophagy has been shown to have diverse implications for normal cell homeostasis, cancer cell survival, and signaling to cells in the tumor microenvironment. Among these implications and of relevance for cancer therapy, the autophagic process is known to be involved in the regulation of protein secretion, in tumor cell immunogenicity, and in the regulation of epithelial-to-mesenchymal transition (EMT), a critical step in the process of cancer cell invasion. In this work, we have reviewed recent evidence linking autophagy to the regulation of EMT in cancer and normal epithelial cells, and have discussed important implications for the manipulation of autophagy during cancer therapy. |
| first_indexed | 2024-03-12T07:06:47Z |
| format | Article |
| id | doaj.art-0547e592c3284a278c51c366f53ab654 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T07:06:47Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-0547e592c3284a278c51c366f53ab6542023-09-02T23:21:01ZengMDPI AGBiology2079-77372019-09-01847110.3390/biology8040071biology8040071Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns CounterproductiveGuadalupe Rojas-Sanchez0Israel Cotzomi-Ortega1Nidia G. Pazos-Salazar2Julio Reyes-Leyva3Paola Maycotte4Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Puebla 72570, MexicoFacultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Puebla 72570, MexicoFacultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Puebla 72570, MexicoCentro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Km 4.5 Carretera Atlixco-Metepec HGZ5, Puebla 74360, MexicoConsejo Nacional de Ciencia y Tecnología (CONACYT)—CIBIOR, IMSS, Puebla 74360, MexicoThe manipulation of autophagy for cancer therapy has gained recent interest in clinical settings. Although inhibition of autophagy is currently being used in clinical trials for the treatment of several malignancies, autophagy has been shown to have diverse implications for normal cell homeostasis, cancer cell survival, and signaling to cells in the tumor microenvironment. Among these implications and of relevance for cancer therapy, the autophagic process is known to be involved in the regulation of protein secretion, in tumor cell immunogenicity, and in the regulation of epithelial-to-mesenchymal transition (EMT), a critical step in the process of cancer cell invasion. In this work, we have reviewed recent evidence linking autophagy to the regulation of EMT in cancer and normal epithelial cells, and have discussed important implications for the manipulation of autophagy during cancer therapy.https://www.mdpi.com/2079-7737/8/4/71autophagycancercancer therapyEMT |
| spellingShingle | Guadalupe Rojas-Sanchez Israel Cotzomi-Ortega Nidia G. Pazos-Salazar Julio Reyes-Leyva Paola Maycotte Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive Biology autophagy cancer cancer therapy EMT |
| title | Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive |
| title_full | Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive |
| title_fullStr | Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive |
| title_full_unstemmed | Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive |
| title_short | Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive |
| title_sort | autophagy and its relationship to epithelial to mesenchymal transition when autophagy inhibition for cancer therapy turns counterproductive |
| topic | autophagy cancer cancer therapy EMT |
| url | https://www.mdpi.com/2079-7737/8/4/71 |
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