Effects of Antiepileptic Drugs on Bone Density and Metabolism
Many studies have demonstrated that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur on inducing the cytochrome P450 enzyme system, thus decreasing vita...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2017-04-01
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| Series: | Archives of Epilepsy |
| Subjects: | |
| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/effects-of-antiepileptic-drugs-on-bone-density-and/54987
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| Summary: | Many studies have demonstrated that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur on inducing the cytochrome P450 enzyme system, thus decreasing vitamin D levels. However, the reason some antiepileptic drugs that suppress (e.g., valproate) or have no effect on this system also affect vitamin D metabolism is not known. This study explored the effect of classic and new antiepileptic drugs on bone health and calcium metabolism. |
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| ISSN: | 2792-0550 |