Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
Abstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who und...
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| Format: | Article |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85267-6 |
| _version_ | 1818425624987959296 |
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| author | Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu |
| author_facet | Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu |
| author_sort | Yit-Sheung Yap |
| collection | DOAJ |
| description | Abstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who underwent initial AVF surgery at a single institution. Demographic, clinical, biochemistry and AVF parameters were extracted from the electronic records, and the association between these variables and mortality was analyzed by Cox proportional hazards model. A total of 501 patients on hemodialysis (63.4 ± 12.7 years, 57.3% male) were included, and the median observation period was 3.66 years. In multivariate analysis, early failure of AVF (hazard ratio (95% confidence interval): 1.54 (1.06–2.24); p = 0.023) was associated with overall mortality but not cardiovascular mortality. Other identified predictors of overall mortality included older age, peripheral artery disease (PAD), cardiomegaly, higher white blood cell (WBC) count and corrected calcium level, and lower total cholesterol level, while predictors of cardiovascular mortality included older age, coronary artery disease (CAD), PAD and lower hemoglobin level. In conclusion, patients with early AVF failure were associated with increased risk of overall mortality. |
| first_indexed | 2024-12-14T14:16:54Z |
| format | Article |
| id | doaj.art-05495a53b512467d86a3b0f42df90a4e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:16:54Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-05495a53b512467d86a3b0f42df90a4e2022-12-21T22:58:11ZengNature PortfolioScientific Reports2045-23222021-03-011111710.1038/s41598-021-85267-6Association of early failure of arteriovenous fistula with mortality in hemodialysis patientsYit-Sheung Yap0Wen-Che Chi1Cheng-Hao Lin2Yi-Chun Liu3Yi-Wen Wu4Adjunct Lecturer, Department of Nursing, Meiho UniversityDivision of Nephrology, Department of Internal Medicine, Yuan’s General HospitalDivision of Nephrology, Department of Internal Medicine, Yuan’s General HospitalDivision of Nephrology, Department of Internal Medicine, Yuan’s General HospitalChronic Kidney Disease Education Center, Yuan’s General HospitalAbstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who underwent initial AVF surgery at a single institution. Demographic, clinical, biochemistry and AVF parameters were extracted from the electronic records, and the association between these variables and mortality was analyzed by Cox proportional hazards model. A total of 501 patients on hemodialysis (63.4 ± 12.7 years, 57.3% male) were included, and the median observation period was 3.66 years. In multivariate analysis, early failure of AVF (hazard ratio (95% confidence interval): 1.54 (1.06–2.24); p = 0.023) was associated with overall mortality but not cardiovascular mortality. Other identified predictors of overall mortality included older age, peripheral artery disease (PAD), cardiomegaly, higher white blood cell (WBC) count and corrected calcium level, and lower total cholesterol level, while predictors of cardiovascular mortality included older age, coronary artery disease (CAD), PAD and lower hemoglobin level. In conclusion, patients with early AVF failure were associated with increased risk of overall mortality.https://doi.org/10.1038/s41598-021-85267-6 |
| spellingShingle | Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu Association of early failure of arteriovenous fistula with mortality in hemodialysis patients Scientific Reports |
| title | Association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| title_full | Association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| title_fullStr | Association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| title_full_unstemmed | Association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| title_short | Association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| title_sort | association of early failure of arteriovenous fistula with mortality in hemodialysis patients |
| url | https://doi.org/10.1038/s41598-021-85267-6 |
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