Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis
Objective: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. In this review we aimed at investigating the severe and challenging risk factors for HCC in Eastern Mediterranean region. Materials and Methods: A systematic search was conducted from 2000 to December 2022 usi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Verduci Editore
2023-12-01
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| Series: | World Cancer Research Journal |
| Subjects: | |
| Online Access: | https://www.wcrj.net/wp-content/uploads/sites/5/2023/12/e2710.pdf |
| _version_ | 1797374749874061312 |
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| author | M. Abedinpour F. Aghaie A. Bakhshi M. Aghaee S. Hassanipour |
| author_facet | M. Abedinpour F. Aghaie A. Bakhshi M. Aghaee S. Hassanipour |
| author_sort | M. Abedinpour |
| collection | DOAJ |
| description | Objective: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. In this review we aimed at investigating the severe and challenging risk factors for HCC in Eastern Mediterranean region.
Materials and Methods: A systematic search was conducted from 2000 to December 2022 using the Scopus, PubMed, and Web of Science databases. Joanna Briggs Institute Critical appraisal checklist served as the basis for assessing quality. For the analysis, CMA software version 3 was used.
Results: Finally, the meta-analysis included 16 articles. Based on the development, the incidence of HCC significantly decreased from 2000 to 2022 in EMRO countries. There was a significant association between HCC and viral hepatitis (OR=7.8, 95% CI: 4.7-12.9, p<0.001). Also, no meaningful correlation was observed between alcohol users and the development of HCC based on the results. Cigarettes play a non-significant protective role in HCC development (OR: 0.90, 95% CI: 0.55-1.48, p=0.7).
Conclusions: Alcohol consumption and smoking, unlike the virus, have no significant relationship with HCC. There is a possibility that the effect of factors affecting HCC may vary in different geographical areas. |
| first_indexed | 2024-03-08T19:10:13Z |
| format | Article |
| id | doaj.art-05498ff5c70c48f9aa07bb19b00fedb5 |
| institution | Directory Open Access Journal |
| issn | 2372-3416 |
| language | English |
| last_indexed | 2024-03-08T19:10:13Z |
| publishDate | 2023-12-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | World Cancer Research Journal |
| spelling | doaj.art-05498ff5c70c48f9aa07bb19b00fedb52023-12-27T15:36:29ZengVerduci EditoreWorld Cancer Research Journal2372-34162023-12-011010.32113/wcrj_202312_27102710Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysisM. Abedinpour0F. Aghaie1A. Bakhshi2M. Aghaee3S. Hassanipour4Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranObjective: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. In this review we aimed at investigating the severe and challenging risk factors for HCC in Eastern Mediterranean region. Materials and Methods: A systematic search was conducted from 2000 to December 2022 using the Scopus, PubMed, and Web of Science databases. Joanna Briggs Institute Critical appraisal checklist served as the basis for assessing quality. For the analysis, CMA software version 3 was used. Results: Finally, the meta-analysis included 16 articles. Based on the development, the incidence of HCC significantly decreased from 2000 to 2022 in EMRO countries. There was a significant association between HCC and viral hepatitis (OR=7.8, 95% CI: 4.7-12.9, p<0.001). Also, no meaningful correlation was observed between alcohol users and the development of HCC based on the results. Cigarettes play a non-significant protective role in HCC development (OR: 0.90, 95% CI: 0.55-1.48, p=0.7). Conclusions: Alcohol consumption and smoking, unlike the virus, have no significant relationship with HCC. There is a possibility that the effect of factors affecting HCC may vary in different geographical areas.https://www.wcrj.net/wp-content/uploads/sites/5/2023/12/e2710.pdfhepatocellular carcinomaeastern mediterranean regionalcoholhepatitissmoking |
| spellingShingle | M. Abedinpour F. Aghaie A. Bakhshi M. Aghaee S. Hassanipour Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis World Cancer Research Journal hepatocellular carcinoma eastern mediterranean region alcohol hepatitis smoking |
| title | Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis |
| title_full | Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis |
| title_fullStr | Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis |
| title_full_unstemmed | Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis |
| title_short | Viral hepatitis, tobacco and alcohol use and risk of liver cancer in the Eastern Mediterranean region (EMRO) countries: a systematic review and meta-analysis |
| title_sort | viral hepatitis tobacco and alcohol use and risk of liver cancer in the eastern mediterranean region emro countries a systematic review and meta analysis |
| topic | hepatocellular carcinoma eastern mediterranean region alcohol hepatitis smoking |
| url | https://www.wcrj.net/wp-content/uploads/sites/5/2023/12/e2710.pdf |
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