¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro?
<abstract language="eng">Is brown adipose tissue a store of long chain polyunsaturated fatty acids during postnatal developing brain?. Mammals along their early postnatal period develop a substantial amount of a very active brown adipose tissue (BAT). Through this work we explored th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedad Latinoamericana de Nutrición
2007-03-01
|
| Series: | Archivos Latinoamericanos de Nutrición |
| Subjects: | |
| Online Access: | http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0004-06222007000100001 |
| _version_ | 1797970694434193408 |
|---|---|
| author | Venezuela Azavache Carmen Cuevas Virgilio Bosch R |
| author_facet | Venezuela Azavache Carmen Cuevas Virgilio Bosch R |
| author_sort | Venezuela Azavache |
| collection | DOAJ |
| description | <abstract language="eng">Is brown adipose tissue a store of long chain polyunsaturated fatty acids during postnatal developing brain?. Mammals along their early postnatal period develop a substantial amount of a very active brown adipose tissue (BAT). Through this work we explored the possibility that BAT may function as a long chain polyunsaturated fatty acids reservoir (LC-PUFA) during the rapid growth of brain structures. In new born rats 1, 6, 12 and 20 days old, we analyzed fatty acid percentage of triglycerides (TG) and phospholipid fractions, and the absolute amount of TG. In 6 day old rats we also evaluated the extend of further desaturation of 1-14C linoleic acid administered by intraperitoneal injection. Results demonstrated a drastic increase of TG concentration during experimental period (1,5; 40; 118; 120 mg/g wet weight) and LCPUFA percentage was higher in "1 and 6" than "12 and 20" days old rats (16-17% vs 5%). Our results showed that BAT stored important amounts of LC-PUFA. On the other hand, 1-14C linoleic acid incorporation was higher in liver than BAT. In contrast, the desaturated products of 1-14C linoleic acid /1-14C linoleic acid ratio was greater in BAT than liver (>4). This could indicate that BAT synthesizes LC-PUFA in addition to store it. In summary we demonstrated than BAT is an important reservoir of LC-PUFA during postnatal brain growth. |
| first_indexed | 2024-04-11T03:19:58Z |
| format | Article |
| id | doaj.art-054d7235bd0e4064b2c3d963b42eec12 |
| institution | Directory Open Access Journal |
| issn | 0004-0622 |
| language | English |
| last_indexed | 2024-04-11T03:19:58Z |
| publishDate | 2007-03-01 |
| publisher | Sociedad Latinoamericana de Nutrición |
| record_format | Article |
| series | Archivos Latinoamericanos de Nutrición |
| spelling | doaj.art-054d7235bd0e4064b2c3d963b42eec122023-01-02T09:05:44ZengSociedad Latinoamericana de NutriciónArchivos Latinoamericanos de Nutrición0004-06222007-03-0157159¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro?Venezuela AzavacheCarmen CuevasVirgilio Bosch R<abstract language="eng">Is brown adipose tissue a store of long chain polyunsaturated fatty acids during postnatal developing brain?. Mammals along their early postnatal period develop a substantial amount of a very active brown adipose tissue (BAT). Through this work we explored the possibility that BAT may function as a long chain polyunsaturated fatty acids reservoir (LC-PUFA) during the rapid growth of brain structures. In new born rats 1, 6, 12 and 20 days old, we analyzed fatty acid percentage of triglycerides (TG) and phospholipid fractions, and the absolute amount of TG. In 6 day old rats we also evaluated the extend of further desaturation of 1-14C linoleic acid administered by intraperitoneal injection. Results demonstrated a drastic increase of TG concentration during experimental period (1,5; 40; 118; 120 mg/g wet weight) and LCPUFA percentage was higher in "1 and 6" than "12 and 20" days old rats (16-17% vs 5%). Our results showed that BAT stored important amounts of LC-PUFA. On the other hand, 1-14C linoleic acid incorporation was higher in liver than BAT. In contrast, the desaturated products of 1-14C linoleic acid /1-14C linoleic acid ratio was greater in BAT than liver (>4). This could indicate that BAT synthesizes LC-PUFA in addition to store it. In summary we demonstrated than BAT is an important reservoir of LC-PUFA during postnatal brain growth.http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0004-06222007000100001Lípidostejido adiposo marróncerebroácido docosahexaenicoácido araquidónicoLipidsbrown adipose tissuebrainarachidonic aciddocosahexaenoic acid |
| spellingShingle | Venezuela Azavache Carmen Cuevas Virgilio Bosch R ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? Archivos Latinoamericanos de Nutrición Lípidos tejido adiposo marrón cerebro ácido docosahexaenico ácido araquidónico Lipids brown adipose tissue brain arachidonic acid docosahexaenoic acid |
| title | ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? |
| title_full | ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? |
| title_fullStr | ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? |
| title_full_unstemmed | ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? |
| title_short | ¿Funciona el tejido adiposo marrón como un depósito de ácidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro? |
| title_sort | funciona el tejido adiposo marron como un deposito de acidos grasos poliinsaturados de cadena larga durante el desarrollo postnatal del cerebro |
| topic | Lípidos tejido adiposo marrón cerebro ácido docosahexaenico ácido araquidónico Lipids brown adipose tissue brain arachidonic acid docosahexaenoic acid |
| url | http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0004-06222007000100001 |
| work_keys_str_mv | AT venezuelaazavache funcionaeltejidoadiposomarroncomoundepositodeacidosgrasospoliinsaturadosdecadenalargaduranteeldesarrollopostnataldelcerebro AT carmencuevas funcionaeltejidoadiposomarroncomoundepositodeacidosgrasospoliinsaturadosdecadenalargaduranteeldesarrollopostnataldelcerebro AT virgilioboschr funcionaeltejidoadiposomarroncomoundepositodeacidosgrasospoliinsaturadosdecadenalargaduranteeldesarrollopostnataldelcerebro |