Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis
Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides dual humoral responses that create a symbiotic environment for the resident gut microbiota and prevent the invasion of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/10/2117 |
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| author | Ahmed A. Abokor Grant H. McDaniel Rachel M. Golonka Connor Campbell Sreya Brahmandam Beng San Yeoh Bina Joe Matam Vijay-Kumar Piu Saha |
| author_facet | Ahmed A. Abokor Grant H. McDaniel Rachel M. Golonka Connor Campbell Sreya Brahmandam Beng San Yeoh Bina Joe Matam Vijay-Kumar Piu Saha |
| author_sort | Ahmed A. Abokor |
| collection | DOAJ |
| description | Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides dual humoral responses that create a symbiotic environment for the resident gut microbiota and prevent the invasion of enteric pathogens. This review features recent immunological and microbial studies that elucidate the underlying IgA and microbiota-dependent mechanisms for mutualism at physiological conditions. IgA derailment and concurrent microbiota instability in pathological diseases are also discussed in detail. Highlights of this review underscore that the source of IgA and its structural form can dictate microbiota reactivity to sustain a diverse niche where both host and bacteria benefit. Other important studies emphasize IgA insufficiency can result in the bloom of opportunistic pathogens that encroach the intestinal epithelia and disseminate into circulation. The continual growth of knowledge in these subjects can lead to the development of therapeutics targeting IgA and/or the microbiota to treat life threatening diseases. |
| first_indexed | 2024-03-10T06:21:41Z |
| format | Article |
| id | doaj.art-054deaac2e60444d8d9f9f84e80f6dbe |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T06:21:41Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-054deaac2e60444d8d9f9f84e80f6dbe2023-11-22T19:14:34ZengMDPI AGMicroorganisms2076-26072021-10-01910211710.3390/microorganisms9102117Immunoglobulin A, an Active Liaison for Host-Microbiota HomeostasisAhmed A. Abokor0Grant H. McDaniel1Rachel M. Golonka2Connor Campbell3Sreya Brahmandam4Beng San Yeoh5Bina Joe6Matam Vijay-Kumar7Piu Saha8Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USACollege of Medicine, University of Toledo, Toledo, OH 43614, USADepartment of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USACollege of Medicine, University of Toledo, Toledo, OH 43614, USACollege of Medicine, University of Toledo, Toledo, OH 43614, USADepartment of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USADepartment of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USADepartment of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USADepartment of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USAMucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides dual humoral responses that create a symbiotic environment for the resident gut microbiota and prevent the invasion of enteric pathogens. This review features recent immunological and microbial studies that elucidate the underlying IgA and microbiota-dependent mechanisms for mutualism at physiological conditions. IgA derailment and concurrent microbiota instability in pathological diseases are also discussed in detail. Highlights of this review underscore that the source of IgA and its structural form can dictate microbiota reactivity to sustain a diverse niche where both host and bacteria benefit. Other important studies emphasize IgA insufficiency can result in the bloom of opportunistic pathogens that encroach the intestinal epithelia and disseminate into circulation. The continual growth of knowledge in these subjects can lead to the development of therapeutics targeting IgA and/or the microbiota to treat life threatening diseases.https://www.mdpi.com/2076-2607/9/10/2117secretory IgAgut homeostasisIgA deficiencypolymeric immunoglobulin receptor (pIgR)mucosal immunologyB cells |
| spellingShingle | Ahmed A. Abokor Grant H. McDaniel Rachel M. Golonka Connor Campbell Sreya Brahmandam Beng San Yeoh Bina Joe Matam Vijay-Kumar Piu Saha Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis Microorganisms secretory IgA gut homeostasis IgA deficiency polymeric immunoglobulin receptor (pIgR) mucosal immunology B cells |
| title | Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis |
| title_full | Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis |
| title_fullStr | Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis |
| title_full_unstemmed | Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis |
| title_short | Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis |
| title_sort | immunoglobulin a an active liaison for host microbiota homeostasis |
| topic | secretory IgA gut homeostasis IgA deficiency polymeric immunoglobulin receptor (pIgR) mucosal immunology B cells |
| url | https://www.mdpi.com/2076-2607/9/10/2117 |
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