Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells
Mycobacterium tuberculosis (Mtb), the causative organism of pulmonary tuberculosis (PTB) now infects more than half of the world population. The efficient transmission strategy of the pathogen includes first remaining dormant inside the infected host, next undergoing reactivation to cause post-prima...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.594572/full |
| _version_ | 1819073575628308480 |
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| author | Lekhika Pathak Lekhika Pathak Bikul Das Bikul Das Bikul Das |
| author_facet | Lekhika Pathak Lekhika Pathak Bikul Das Bikul Das Bikul Das |
| author_sort | Lekhika Pathak |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (Mtb), the causative organism of pulmonary tuberculosis (PTB) now infects more than half of the world population. The efficient transmission strategy of the pathogen includes first remaining dormant inside the infected host, next undergoing reactivation to cause post-primary tuberculosis of the lungs (PPTBL) and then transmit via aerosol to the community. In this review, we are exploring recent findings on the role of bone marrow (BM) stem cell niche in Mtb dormancy and reactivation that may underlie the mechanisms of PPTBL development. We suggest that pathogen’s interaction with the stem cell niche may be relevant in potential inflammation induced PPTBL reactivation, which need significant research attention for the future development of novel preventive and therapeutic strategies for PPTBL, especially in a post COVID-19 pandemic world. Finally, we put forward potential animal models to study the stem cell basis of Mtb dormancy and reactivation. |
| first_indexed | 2024-12-21T17:55:48Z |
| format | Article |
| id | doaj.art-0550771d5fe443efa017cd606af74e0f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T17:55:48Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0550771d5fe443efa017cd606af74e0f2022-12-21T18:55:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-01-011110.3389/fimmu.2020.594572594572Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem CellsLekhika Pathak0Lekhika Pathak1Bikul Das2Bikul Das3Bikul Das4Department of Stem Cell and Infectious Diseases, KaviKrishna Laboratory, Guwahati Biotech Park, Indian Institute of Technology, Guwahati, IndiaKaviKrishna Telemedicine Care, Sualkuchi, IndiaDepartment of Stem Cell and Infectious Diseases, KaviKrishna Laboratory, Guwahati Biotech Park, Indian Institute of Technology, Guwahati, IndiaKaviKrishna Telemedicine Care, Sualkuchi, IndiaDepartment of Stem Cell and Infection, Thoreau Laboratory for Global Health, M2D2, University of Massachusetts, Lowell, MA, United StatesMycobacterium tuberculosis (Mtb), the causative organism of pulmonary tuberculosis (PTB) now infects more than half of the world population. The efficient transmission strategy of the pathogen includes first remaining dormant inside the infected host, next undergoing reactivation to cause post-primary tuberculosis of the lungs (PPTBL) and then transmit via aerosol to the community. In this review, we are exploring recent findings on the role of bone marrow (BM) stem cell niche in Mtb dormancy and reactivation that may underlie the mechanisms of PPTBL development. We suggest that pathogen’s interaction with the stem cell niche may be relevant in potential inflammation induced PPTBL reactivation, which need significant research attention for the future development of novel preventive and therapeutic strategies for PPTBL, especially in a post COVID-19 pandemic world. Finally, we put forward potential animal models to study the stem cell basis of Mtb dormancy and reactivation.https://www.frontiersin.org/articles/10.3389/fimmu.2020.594572/fullpost-primary tuberculosis of the lungsdormancyreactivationstem cell nichebone marrow derived stem cellsaltruistic stem cells |
| spellingShingle | Lekhika Pathak Lekhika Pathak Bikul Das Bikul Das Bikul Das Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells Frontiers in Immunology post-primary tuberculosis of the lungs dormancy reactivation stem cell niche bone marrow derived stem cells altruistic stem cells |
| title | Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells |
| title_full | Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells |
| title_fullStr | Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells |
| title_full_unstemmed | Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells |
| title_short | Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells |
| title_sort | initiation of post primary tuberculosis of the lungs exploring the secret role of bone marrow derived stem cells |
| topic | post-primary tuberculosis of the lungs dormancy reactivation stem cell niche bone marrow derived stem cells altruistic stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.594572/full |
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