Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2

Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2

Abstract Rett syndrome (RTT) is a progressive neurodevelopmental disorder, mainly caused by mutations in MeCP2 and currently with no cure. We report here that neurons from R106W MeCP2 RTT human iPSCs as well as human embryonic stem cells after MeCP2 knockdown exhibit consistent and long-lasting impa...

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Manylion Llyfryddiaeth
Prif Awduron:	Xiaoying Chen, Xu Han, Bruno Blanchi, Wuqiang Guan, Weihong Ge, Yong-Chun Yu, Yi E. Sun
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Oxford University Press 2020-08-01
Cyfres:	Protein & Cell
Pynciau:	MeCP2 Rett Syndrome human pluripotent stem cell neural differentiation
Mynediad Ar-lein:	https://doi.org/10.1007/s13238-020-00773-z

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