Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

Abstract DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting. Thus, we aimed to conduct a comprehensive analysis of DDR genes in GBM specimens to...

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Bibliographic Details
Main Authors: Wen-Bin Yang, An-Chih Wu, Tsung-I Hsu, Jing-Ping Liou, Wei-Lun Lo, Kwang-Yu Chang, Pin-Yuan Chen, Ushio Kikkawa, Shung-Tai Yang, Tzu-Jen Kao, Ruei-Ming Chen, Wen-Chang Chang, Chiung-Yuan Ko, Jian-Ying Chuang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04182-w

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