Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Abstract Background Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways. Recent data have shown that MPL function is essential...

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Bibliographic Details
Main Authors: Lijuan Han, Claudia Schubert, Johanna Köhler, Mirle Schemionek, Susanne Isfort, Tim H. Brümmendorf, Steffen Koschmieder, Nicolas Chatain
Format: Article
Language:English
Published: BMC 2016-05-01
Series:Journal of Hematology & Oncology
Subjects:
Calreticulin
Frameshift mutants
del52
Myeloproliferative neoplasms
MPN
Megakaryopoiesis
Online Access:http://link.springer.com/article/10.1186/s13045-016-0275-0

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