N-acetylcysteine prevents spatial memory impairment induced by chronic early postnatal glutaric acid and lipopolysaccharide in rat pups.

N-acetylcysteine prevents spatial memory impairment induced by chronic early postnatal glutaric acid and lipopolysaccharide in rat pups.

BACKGROUND AND AIMS:Glutaric aciduria type I (GA-I) is characterized by accumulation of glutaric acid (GA) and neurological symptoms, such as cognitive impairment. Although this disease is related to oxidative stress and inflammation, it is not known whether these processes facilitate the memory imp...

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Main Authors: Fernanda S Rodrigues, Mauren A Souza, Danieli V Magni, Ana Paula O Ferreira, Bibiana C Mota, Andreia M Cardoso, Mariana Paim, Léder L Xavier, Juliano Ferreira, Maria Rosa C Schetinger, Jaderson C Da Costa, Luiz Fernando F Royes, Michele R Fighera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3813430?pdf=render

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