Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria
It is well established that CNS axons fail to regenerate, undergo retrograde dieback, and form dystrophic growth cones due to both intrinsic and extrinsic factors. We sought to investigate the role of axonal mitochondria in the axonal response to injury. A viral vector (AAV) containing a mitochondri...
Main Authors: | Joseph Kedra, Shen Lin, Almudena Pacheco, Gianluca Gallo, George M. Smith |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-06-01
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Series: | Frontiers in Molecular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.668670/full |
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