Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department
Backgroundinternational guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children.MethodsBetween 1st January and 30th September 2...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1075449/full |
| _version_ | 1811157728602619904 |
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| author | Elena Chiappini Elena Chiappini Matilde Bestetti Matilde Bestetti Stefano Masi Stefano Masi Teresa Paba Teresa Paba Elisabetta Venturini Elisabetta Venturini Luisa Galli Luisa Galli |
| author_facet | Elena Chiappini Elena Chiappini Matilde Bestetti Matilde Bestetti Stefano Masi Stefano Masi Teresa Paba Teresa Paba Elisabetta Venturini Elisabetta Venturini Luisa Galli Luisa Galli |
| author_sort | Elena Chiappini |
| collection | DOAJ |
| description | Backgroundinternational guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children.MethodsBetween 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally. For each child, body temperature, presence and severity of discomfort, defined using a previously published semiquantitative likert scale, were evaluated at baseline and 60 min after administration of paracetamol, and differences were analyzed.Results172 children (males: 91/172; 52.9%; median age: 41.7 months) were included. Significant reductions in body temperature (median body temperature at T0: 38.9 °C; IQR: 38.3–39.4, median body temperature at T60: 36.9 °C; IQR: 36.4–37.5; P < 0.0001), and in the level of discomfort (proportion of children with severe discomfort at T0: 85% and at T60:14%; P < 0.0001) were observed. Severe discomfort at T60 persisted in a minority of children (24/172; 14%) and it was not related to body temperature values.Conclusionsparacetamol in febrile children is associated not only with significantly reduction in body temperature but also with discomfort relief. |
| first_indexed | 2024-04-10T05:12:14Z |
| format | Article |
| id | doaj.art-05549b22517f40b3a9ac50e25a0003fc |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T05:12:14Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-05549b22517f40b3a9ac50e25a0003fc2023-03-09T06:38:39ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.10754491075449Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency departmentElena Chiappini0Elena Chiappini1Matilde Bestetti2Matilde Bestetti3Stefano Masi4Stefano Masi5Teresa Paba6Teresa Paba7Elisabetta Venturini8Elisabetta Venturini9Luisa Galli10Luisa Galli11Pediatric Infectious Disease Unit, Anna Meyer Children's University Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyPediatric Infectious Disease Unit, Anna Meyer Children's University Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyDepartment of Emergency Medicine, Anna Meyer Children's University Hospital, Florence, ItalyPediatric Infectious Disease Unit, Anna Meyer Children's University Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyPediatric Infectious Disease Unit, Anna Meyer Children's University Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyPediatric Infectious Disease Unit, Anna Meyer Children's University Hospital, Florence, ItalyDepartment of Health Sciences, University of Florence, Florence, ItalyBackgroundinternational guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children.MethodsBetween 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally. For each child, body temperature, presence and severity of discomfort, defined using a previously published semiquantitative likert scale, were evaluated at baseline and 60 min after administration of paracetamol, and differences were analyzed.Results172 children (males: 91/172; 52.9%; median age: 41.7 months) were included. Significant reductions in body temperature (median body temperature at T0: 38.9 °C; IQR: 38.3–39.4, median body temperature at T60: 36.9 °C; IQR: 36.4–37.5; P < 0.0001), and in the level of discomfort (proportion of children with severe discomfort at T0: 85% and at T60:14%; P < 0.0001) were observed. Severe discomfort at T60 persisted in a minority of children (24/172; 14%) and it was not related to body temperature values.Conclusionsparacetamol in febrile children is associated not only with significantly reduction in body temperature but also with discomfort relief.https://www.frontiersin.org/articles/10.3389/fped.2023.1075449/fulldiscomfortfebrile childrenfever, paracetamolAcetaminophen |
| spellingShingle | Elena Chiappini Elena Chiappini Matilde Bestetti Matilde Bestetti Stefano Masi Stefano Masi Teresa Paba Teresa Paba Elisabetta Venturini Elisabetta Venturini Luisa Galli Luisa Galli Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department Frontiers in Pediatrics discomfort febrile children fever, paracetamol Acetaminophen |
| title | Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| title_full | Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| title_fullStr | Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| title_full_unstemmed | Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| title_short | Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| title_sort | discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department |
| topic | discomfort febrile children fever, paracetamol Acetaminophen |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1075449/full |
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