Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
Abstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected...
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-83989-1 |
| _version_ | 1818852025805307904 |
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| author | Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler |
| author_facet | Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler |
| author_sort | Virginie Kreutzinger |
| collection | DOAJ |
| description | Abstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected by high-resolution CT. Included in this IRB-approved retrospective case–control study were 56 patients with asymptomatic sHPT as well as 259 matched controls without SIJ disease. Demographic data were retrieved from electronic patient records. High-resolution computed tomography datasets of all patients were subjected to a structured scoring, including erosions, sclerosis, osteophytes, joint space alterations and intraarticular calcifications. Chi2 tests were used to compare frequencies of lesions. Erosions were significantly more prevalent in patients with sHPT, and were found mainly in the ventral (28.6% vs. 13.9%; p = 0.016) and middle (17.9% vs. 7.7%; p = 0.040) iliac portions of the SIJ. Partial ankylosis was rare in both cohorts (3.6% vs. 5.0%; p > 0.999); complete ankylosis was not observed. Neither extent not prevalence of sclerosis or calcifications differed significantly between groups. Joint lesions reminiscent of sacroiliitis can be found in a substantial portion of asymptomatic patients with secondary hyperparathyroidism. Further investigations into the clinical significance of these findings are warranted. |
| first_indexed | 2024-12-19T07:14:22Z |
| format | Article |
| id | doaj.art-0555cc101e2a4bca9f64b23de415bfa6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T07:14:22Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0555cc101e2a4bca9f64b23de415bfa62022-12-21T20:31:06ZengNature PortfolioScientific Reports2045-23222021-02-011111610.1038/s41598-021-83989-1Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomographyVirginie Kreutzinger0Torsten Diekhoff1Lutz Liefeldt2Denis Poddubnyy3Kay Geert A. Hermann4Katharina Ziegeler5Department of Radiology, Vivantes Klinikum im FriedrichshainDepartment of Radiology, Charité-Universitätsmedizin BerlinDepartment of Nephrology and Internal Intensive Care Medicine, Charité-Universitätsmedizin BerlinDepartment of Rheumatology, Charité-Universitätsmedizin BerlinDepartment of Radiology, Charité-Universitätsmedizin BerlinDepartment of Radiology, Charité-Universitätsmedizin BerlinAbstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected by high-resolution CT. Included in this IRB-approved retrospective case–control study were 56 patients with asymptomatic sHPT as well as 259 matched controls without SIJ disease. Demographic data were retrieved from electronic patient records. High-resolution computed tomography datasets of all patients were subjected to a structured scoring, including erosions, sclerosis, osteophytes, joint space alterations and intraarticular calcifications. Chi2 tests were used to compare frequencies of lesions. Erosions were significantly more prevalent in patients with sHPT, and were found mainly in the ventral (28.6% vs. 13.9%; p = 0.016) and middle (17.9% vs. 7.7%; p = 0.040) iliac portions of the SIJ. Partial ankylosis was rare in both cohorts (3.6% vs. 5.0%; p > 0.999); complete ankylosis was not observed. Neither extent not prevalence of sclerosis or calcifications differed significantly between groups. Joint lesions reminiscent of sacroiliitis can be found in a substantial portion of asymptomatic patients with secondary hyperparathyroidism. Further investigations into the clinical significance of these findings are warranted.https://doi.org/10.1038/s41598-021-83989-1 |
| spellingShingle | Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography Scientific Reports |
| title | Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| title_full | Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| title_fullStr | Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| title_full_unstemmed | Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| title_short | Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| title_sort | asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography |
| url | https://doi.org/10.1038/s41598-021-83989-1 |
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