Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers
BackgroundThe relationship between endometrial thickness and pregnancy safety after in vitro fertilization treatment is an important topic that should provoke attention. The aim of this study was to demonstrate the relationship between endometrial thickness on day of embryo transfer and early pregna...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1066922/full |
| _version_ | 1797740074167697408 |
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| author | Lin Song Lin Song Lin Song Lin Song Zhiqin Bu Zhiqin Bu Zhiqin Bu Zhiqin Bu Yingpu Sun Yingpu Sun Yingpu Sun Yingpu Sun |
| author_facet | Lin Song Lin Song Lin Song Lin Song Zhiqin Bu Zhiqin Bu Zhiqin Bu Zhiqin Bu Yingpu Sun Yingpu Sun Yingpu Sun Yingpu Sun |
| author_sort | Lin Song |
| collection | DOAJ |
| description | BackgroundThe relationship between endometrial thickness and pregnancy safety after in vitro fertilization treatment is an important topic that should provoke attention. The aim of this study was to demonstrate the relationship between endometrial thickness on day of embryo transfer and early pregnancy complications, including ectopic pregnancy and early miscarriage, in frozen thawed embryo transfer (FET) cycles.MethodsPatients undergoing their first FET cycles were included into this study from January 2010 to December 2021. Patients were divided into three groups according to endometrial thickness on day of embryo transfer: Thin, ≤ 7 mm; Medium, 7-14 mm; Thick, ≥ 14 mm. Ectopic pregnancy and early miscarriage were the two primary outcomes. Endometrial thickness was the main measured variable. The risk factors of these two compilations were determined based on univariate analysis and multivariate logistic regression analysis.ResultsA total of 11138 clinical pregnancies were included. The overall ectopic pregnancy and early spontaneous miscarriage rates were 2.62% and 13.40%. The ectopic pregnancy and early spontaneous miscarriage rates were significantly higher in patients with thin endometrium as compared with those in the other two groups (ectopic pregnancy rate: 5.06% vs. 2.62% vs. 1.05%; P < 0.001; early spontaneous miscarriage rate: 15.18% vs. 13.45% vs. 11.53%; P < 0.001). In multivariate logistic regression analysis, thin endometrium was an independent factor to predict ectopic pregnancy [adjusted odds ratio (aOR): 5.62; 95% confidence interval (CI): 2.51–12.58, P < 0.001], and to predict early spontaneous miscarriage rate (aOR: 1.57; 95% CI: 1.21–1.74, P < 0.001).ConclusionThin endometrium on day of embryo transfer in FET cycles is an independent predictor for early pregnancy compilations, including ectopic pregnancy and early spontaneous miscarriage. |
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| format | Article |
| id | doaj.art-05568cc506af47bca077005f9fdcb3d9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T14:07:17Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-05568cc506af47bca077005f9fdcb3d92023-08-21T13:31:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.10669221066922Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfersLin Song0Lin Song1Lin Song2Lin Song3Zhiqin Bu4Zhiqin Bu5Zhiqin Bu6Zhiqin Bu7Yingpu Sun8Yingpu Sun9Yingpu Sun10Yingpu Sun11Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundThe relationship between endometrial thickness and pregnancy safety after in vitro fertilization treatment is an important topic that should provoke attention. The aim of this study was to demonstrate the relationship between endometrial thickness on day of embryo transfer and early pregnancy complications, including ectopic pregnancy and early miscarriage, in frozen thawed embryo transfer (FET) cycles.MethodsPatients undergoing their first FET cycles were included into this study from January 2010 to December 2021. Patients were divided into three groups according to endometrial thickness on day of embryo transfer: Thin, ≤ 7 mm; Medium, 7-14 mm; Thick, ≥ 14 mm. Ectopic pregnancy and early miscarriage were the two primary outcomes. Endometrial thickness was the main measured variable. The risk factors of these two compilations were determined based on univariate analysis and multivariate logistic regression analysis.ResultsA total of 11138 clinical pregnancies were included. The overall ectopic pregnancy and early spontaneous miscarriage rates were 2.62% and 13.40%. The ectopic pregnancy and early spontaneous miscarriage rates were significantly higher in patients with thin endometrium as compared with those in the other two groups (ectopic pregnancy rate: 5.06% vs. 2.62% vs. 1.05%; P < 0.001; early spontaneous miscarriage rate: 15.18% vs. 13.45% vs. 11.53%; P < 0.001). In multivariate logistic regression analysis, thin endometrium was an independent factor to predict ectopic pregnancy [adjusted odds ratio (aOR): 5.62; 95% confidence interval (CI): 2.51–12.58, P < 0.001], and to predict early spontaneous miscarriage rate (aOR: 1.57; 95% CI: 1.21–1.74, P < 0.001).ConclusionThin endometrium on day of embryo transfer in FET cycles is an independent predictor for early pregnancy compilations, including ectopic pregnancy and early spontaneous miscarriage.https://www.frontiersin.org/articles/10.3389/fendo.2023.1066922/fullendometrial thicknessfrozen thawed embryo transferectopic pregnancyearly spontaneous miscarriagepregnancy complications |
| spellingShingle | Lin Song Lin Song Lin Song Lin Song Zhiqin Bu Zhiqin Bu Zhiqin Bu Zhiqin Bu Yingpu Sun Yingpu Sun Yingpu Sun Yingpu Sun Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers Frontiers in Endocrinology endometrial thickness frozen thawed embryo transfer ectopic pregnancy early spontaneous miscarriage pregnancy complications |
| title | Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers |
| title_full | Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers |
| title_fullStr | Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers |
| title_full_unstemmed | Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers |
| title_short | Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers |
| title_sort | endometrial thickness and early pregnancy complications after frozen thawed embryo transfers |
| topic | endometrial thickness frozen thawed embryo transfer ectopic pregnancy early spontaneous miscarriage pregnancy complications |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1066922/full |
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