Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review
ABSTRACT Importance Urinary tract infection (UTI) is one of the most common infections encountered in infancy and childhood. Despite the emerging problem of antibiotic resistance in recent years, the use of antibiotics for better management of UTIs is inevitable. Objective This study aims to explore...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
|
| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12375 |
| _version_ | 1797805331786498048 |
|---|---|
| author | Rifat Ara Sarker Mohammad Nasrullah Zarrin Tasnim Sadia Afrin Mohammad Delwer Hossain Hawlader KM Saif‐Ur‐Rahman |
| author_facet | Rifat Ara Sarker Mohammad Nasrullah Zarrin Tasnim Sadia Afrin Mohammad Delwer Hossain Hawlader KM Saif‐Ur‐Rahman |
| author_sort | Rifat Ara |
| collection | DOAJ |
| description | ABSTRACT Importance Urinary tract infection (UTI) is one of the most common infections encountered in infancy and childhood. Despite the emerging problem of antibiotic resistance in recent years, the use of antibiotics for better management of UTIs is inevitable. Objective This study aims to explore the efficacy and adverse effects of the available antimicrobial agents that are used in pediatric UTIs in low‐ and middle‐income countries (LMICs). Methods Five electronic databases were searched to identify relevant articles. Two reviewers independently performed screening, data extraction, and quality assessment of the available literature. Randomized controlled trials providing antimicrobial interventions in both male and female participants within the age range of 3 months to 17 years in LMICs were included. Results Six randomized controlled trials from 13 LMICs were included in this review (four trials explored the efficacy). Due to high heterogeneity across the studies, a meta‐analysis was not performed. Other than attrition and reporting bias, the risk of bias was moderate to high due to poor study designs. The differences in the efficacy and adverse events of different antimicrobials were not found to be statistically significant. Interpretation This review indicates the necessity for additional clinical trials on children from LMICs with more significant sample numbers, adequate intervention periods, and study design. |
| first_indexed | 2024-03-13T05:50:28Z |
| format | Article |
| id | doaj.art-0556f62a81714c459a3e592c7931b179 |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-03-13T05:50:28Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-0556f62a81714c459a3e592c7931b1792023-06-13T13:05:31ZengWileyPediatric Investigation2574-22722023-06-017210211010.1002/ped4.12375Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic reviewRifat Ara0Sarker Mohammad Nasrullah1Zarrin Tasnim2Sadia Afrin3Mohammad Delwer Hossain Hawlader4KM Saif‐Ur‐Rahman5Infectious Disease Division icddr,b Dhaka BangladeshMaternal and Child Health Division icddr,b Dhaka BangladeshPublic Health Professional Development Society (PPDS) Dhaka BangladeshHealth System and Population Studies Division icddr,b Dhaka BangladeshDepartment of Public Health North South University Dhaka BangladeshHealth System and Population Studies Division icddr,b Dhaka BangladeshABSTRACT Importance Urinary tract infection (UTI) is one of the most common infections encountered in infancy and childhood. Despite the emerging problem of antibiotic resistance in recent years, the use of antibiotics for better management of UTIs is inevitable. Objective This study aims to explore the efficacy and adverse effects of the available antimicrobial agents that are used in pediatric UTIs in low‐ and middle‐income countries (LMICs). Methods Five electronic databases were searched to identify relevant articles. Two reviewers independently performed screening, data extraction, and quality assessment of the available literature. Randomized controlled trials providing antimicrobial interventions in both male and female participants within the age range of 3 months to 17 years in LMICs were included. Results Six randomized controlled trials from 13 LMICs were included in this review (four trials explored the efficacy). Due to high heterogeneity across the studies, a meta‐analysis was not performed. Other than attrition and reporting bias, the risk of bias was moderate to high due to poor study designs. The differences in the efficacy and adverse events of different antimicrobials were not found to be statistically significant. Interpretation This review indicates the necessity for additional clinical trials on children from LMICs with more significant sample numbers, adequate intervention periods, and study design.https://doi.org/10.1002/ped4.12375Antimicrobial agentsChildrenEfficacyLMICsUrinary tract infection |
| spellingShingle | Rifat Ara Sarker Mohammad Nasrullah Zarrin Tasnim Sadia Afrin Mohammad Delwer Hossain Hawlader KM Saif‐Ur‐Rahman Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review Pediatric Investigation Antimicrobial agents Children Efficacy LMICs Urinary tract infection |
| title | Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review |
| title_full | Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review |
| title_fullStr | Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review |
| title_full_unstemmed | Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review |
| title_short | Effective antimicrobial therapies of urinary tract infections among children in low‐ and middle‐income countries: A systematic review |
| title_sort | effective antimicrobial therapies of urinary tract infections among children in low and middle income countries a systematic review |
| topic | Antimicrobial agents Children Efficacy LMICs Urinary tract infection |
| url | https://doi.org/10.1002/ped4.12375 |
| work_keys_str_mv | AT rifatara effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview AT sarkermohammadnasrullah effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview AT zarrintasnim effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview AT sadiaafrin effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview AT mohammaddelwerhossainhawlader effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview AT kmsaifurrahman effectiveantimicrobialtherapiesofurinarytractinfectionsamongchildreninlowandmiddleincomecountriesasystematicreview |