Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis
Background At present, it has been controversial whether primary tumor resection (PTR) can bring survival advantage to patients with metastatic small intestine neuroendocrine tumors (SI-NETs). To answer this question, we conducted a retrospective cohort study to evaluate the effect of PTR on the sur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-06-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2021.2024306 |
| _version_ | 1797684445713530880 |
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| author | Haihao Yan Linlin Yin Hao Han Ye Jin Zheng Liu |
| author_facet | Haihao Yan Linlin Yin Hao Han Ye Jin Zheng Liu |
| author_sort | Haihao Yan |
| collection | DOAJ |
| description | Background At present, it has been controversial whether primary tumor resection (PTR) can bring survival advantage to patients with metastatic small intestine neuroendocrine tumors (SI-NETs). To answer this question, we conducted a retrospective cohort study to evaluate the effect of PTR on the survival of patients with metastatic SI-NETs. Methods Information on SI-NETs patients from 2004 to 2015 was extracted from Surveillance, Epidemiology, and End Results (SEER) databases. Demographics, tumor characteristics, treatment, and survival were compared. Propensity score-matched (PSM) was used 1:1 in the filtered queue. Cox proportional hazard regression model was used to evaluate the correlation between PTR and treatment results. Results Before PSM, survival analysis showed that PTR significantly prolonged the survival of metastatic SI-NETs patients. After PSM, there was no significant difference in overall survival (OS) and cancer-specific survival (CSS) between the PTR group and the non-PTR group. Multivariate analysis showed no significant difference in OS and CSS between the two groups (p > 0.05). Conclusion Our study shows that OS and CSS are comparable between the PTR group and the non-PTR group. Thus, we believe that PTR should not be actively performed on such patients. Meanwhile, it is undeniable that properly selected patients may also benefit from PTR. Therefore, prospective randomized controlled trials are still needed to verify the effect of PTR on patients in the future. |
| first_indexed | 2024-03-12T00:29:45Z |
| format | Article |
| id | doaj.art-05577ef8343e4bf0a817ad8f6a878916 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:29:45Z |
| publishDate | 2022-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-05577ef8343e4bf0a817ad8f6a8789162023-09-15T10:21:29ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-06-013561239124710.1080/08941939.2021.20243062024306Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched AnalysisHaihao Yan0Linlin Yin1Hao Han2Ye Jin3Zheng Liu4Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical UniversityMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical UniversityMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical UniversityMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical UniversityMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical UniversityBackground At present, it has been controversial whether primary tumor resection (PTR) can bring survival advantage to patients with metastatic small intestine neuroendocrine tumors (SI-NETs). To answer this question, we conducted a retrospective cohort study to evaluate the effect of PTR on the survival of patients with metastatic SI-NETs. Methods Information on SI-NETs patients from 2004 to 2015 was extracted from Surveillance, Epidemiology, and End Results (SEER) databases. Demographics, tumor characteristics, treatment, and survival were compared. Propensity score-matched (PSM) was used 1:1 in the filtered queue. Cox proportional hazard regression model was used to evaluate the correlation between PTR and treatment results. Results Before PSM, survival analysis showed that PTR significantly prolonged the survival of metastatic SI-NETs patients. After PSM, there was no significant difference in overall survival (OS) and cancer-specific survival (CSS) between the PTR group and the non-PTR group. Multivariate analysis showed no significant difference in OS and CSS between the two groups (p > 0.05). Conclusion Our study shows that OS and CSS are comparable between the PTR group and the non-PTR group. Thus, we believe that PTR should not be actively performed on such patients. Meanwhile, it is undeniable that properly selected patients may also benefit from PTR. Therefore, prospective randomized controlled trials are still needed to verify the effect of PTR on patients in the future.http://dx.doi.org/10.1080/08941939.2021.2024306small intestine neuroendocrine tumorsseer databaseprimary tumor resectionsurvival；metastatic |
| spellingShingle | Haihao Yan Linlin Yin Hao Han Ye Jin Zheng Liu Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis Journal of Investigative Surgery small intestine neuroendocrine tumors seer database primary tumor resection survival；metastatic |
| title | Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis |
| title_full | Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis |
| title_fullStr | Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis |
| title_full_unstemmed | Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis |
| title_short | Relationship between Primary Tumor Resection for Metastatic Small Intestine Neuroendocrine Tumors and Survival: A Propensity Score-Matched Analysis |
| title_sort | relationship between primary tumor resection for metastatic small intestine neuroendocrine tumors and survival a propensity score matched analysis |
| topic | small intestine neuroendocrine tumors seer database primary tumor resection survival；metastatic |
| url | http://dx.doi.org/10.1080/08941939.2021.2024306 |
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