Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma
Both subventricular zone (SVZ) contact and isocitrate dehydrogenase 1 (IDH1) mutation have been reported to be related to the outcome of glioma, respectively. However, far too little attention has been paid to the role of tumor edge-SVZ distance in the outcome of glioma. We aim to assess the value o...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.693693/full |
| _version_ | 1818599871573131264 |
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| author | Shuixian Zhang Fengchun Zhao Tengyuan Zhou Dan Liu Xiaohong Yao Wenjuan Fu Zhi Liu Chuan Lan Zhaopan Lai Chen Liu Haitao Li Yuhong Li Shengli Hu Yi Yin Liang Tan Wenyan Li Fei Li Rong Hu Hua Feng |
| author_facet | Shuixian Zhang Fengchun Zhao Tengyuan Zhou Dan Liu Xiaohong Yao Wenjuan Fu Zhi Liu Chuan Lan Zhaopan Lai Chen Liu Haitao Li Yuhong Li Shengli Hu Yi Yin Liang Tan Wenyan Li Fei Li Rong Hu Hua Feng |
| author_sort | Shuixian Zhang |
| collection | DOAJ |
| description | Both subventricular zone (SVZ) contact and isocitrate dehydrogenase 1 (IDH1) mutation have been reported to be related to the outcome of glioma, respectively. However, far too little attention has been paid to the role of tumor edge-SVZ distance in the outcome of glioma. We aim to assess the value of tumor-SVZ distance, as well as combined tumor-SVZ distance and IDH status, in predicting the outcome of gliomas (WHO grade II–IV). Here, the MR images and clinical data from 146 patients were included in the current study. The relationship between survival and the tumor-SVZ distance as well as survival and combination of tumor-SVZ distance and IDH status were determined via univariate and multivariate analyses. In univariate analysis of tumor-SVZ distance, the patients were divided into three types (SVZ involvement, tumor-SVZ distance from 0 to 10 mm, and tumor-SVZ distance >10 mm). The results showed that the OS (p = 0.02) and PFS (p = 0.002) for the patients had a positive correlation with the tumor-SVZ distance. In addition, simple linear correlation found a significant relationship between the two parameters (OS and PFS) and tumor-SVZ distance in patients with non-SVZ-contacting glioma. Combination analysis of the tumor-SVZ distance and IDH status showed that IDH1 mutation and SVZ non-involvement enable favorable outcomes, whereas IDH1 wild type with SVZ involvement indicates a significantly worse prognosis in all patients. Moreover, in patients with non-SVZ-contacting glioma, IDH1 mutation concurrent with tumor-SVZ distance >10 mm has better OS and PFS. IDH1 wild type and tumor-SVZ distance from 0 to 10 mm suggest poorer OS and PFS. Multivariate analysis showed WHO grade IV, SVZ involvement, tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, gross total resection, and chemotherapy serve as independent predictors of OS. WHO grade IV, SVZ involvement, tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, and chemotherapy serve as independent predictors of PFS of patients with glioma. In conclusion, tumor-SVZ distance and IDH1 mutation status are the determinants affecting patient outcome. |
| first_indexed | 2024-12-16T12:26:29Z |
| format | Article |
| id | doaj.art-0557a0d3d07e49a6869536881b5bf936 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T12:26:29Z |
| publishDate | 2021-08-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-0557a0d3d07e49a6869536881b5bf9362022-12-21T22:31:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.693693693693Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With GliomaShuixian Zhang0Fengchun Zhao1Tengyuan Zhou2Dan Liu3Xiaohong Yao4Wenjuan Fu5Zhi Liu6Chuan Lan7Zhaopan Lai8Chen Liu9Haitao Li10Yuhong Li11Shengli Hu12Yi Yin13Liang Tan14Wenyan Li15Fei Li16Rong Hu17Hua Feng18Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaBoth subventricular zone (SVZ) contact and isocitrate dehydrogenase 1 (IDH1) mutation have been reported to be related to the outcome of glioma, respectively. However, far too little attention has been paid to the role of tumor edge-SVZ distance in the outcome of glioma. We aim to assess the value of tumor-SVZ distance, as well as combined tumor-SVZ distance and IDH status, in predicting the outcome of gliomas (WHO grade II–IV). Here, the MR images and clinical data from 146 patients were included in the current study. The relationship between survival and the tumor-SVZ distance as well as survival and combination of tumor-SVZ distance and IDH status were determined via univariate and multivariate analyses. In univariate analysis of tumor-SVZ distance, the patients were divided into three types (SVZ involvement, tumor-SVZ distance from 0 to 10 mm, and tumor-SVZ distance >10 mm). The results showed that the OS (p = 0.02) and PFS (p = 0.002) for the patients had a positive correlation with the tumor-SVZ distance. In addition, simple linear correlation found a significant relationship between the two parameters (OS and PFS) and tumor-SVZ distance in patients with non-SVZ-contacting glioma. Combination analysis of the tumor-SVZ distance and IDH status showed that IDH1 mutation and SVZ non-involvement enable favorable outcomes, whereas IDH1 wild type with SVZ involvement indicates a significantly worse prognosis in all patients. Moreover, in patients with non-SVZ-contacting glioma, IDH1 mutation concurrent with tumor-SVZ distance >10 mm has better OS and PFS. IDH1 wild type and tumor-SVZ distance from 0 to 10 mm suggest poorer OS and PFS. Multivariate analysis showed WHO grade IV, SVZ involvement, tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, gross total resection, and chemotherapy serve as independent predictors of OS. WHO grade IV, SVZ involvement, tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, and chemotherapy serve as independent predictors of PFS of patients with glioma. In conclusion, tumor-SVZ distance and IDH1 mutation status are the determinants affecting patient outcome.https://www.frontiersin.org/articles/10.3389/fonc.2021.693693/fullgliomaMRIsubventricular zoneisocitrate dehydrogenase 1prognosis |
| spellingShingle | Shuixian Zhang Fengchun Zhao Tengyuan Zhou Dan Liu Xiaohong Yao Wenjuan Fu Zhi Liu Chuan Lan Zhaopan Lai Chen Liu Haitao Li Yuhong Li Shengli Hu Yi Yin Liang Tan Wenyan Li Fei Li Rong Hu Hua Feng Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma Frontiers in Oncology glioma MRI subventricular zone isocitrate dehydrogenase 1 prognosis |
| title | Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma |
| title_full | Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma |
| title_fullStr | Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma |
| title_full_unstemmed | Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma |
| title_short | Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma |
| title_sort | combination of the distance from tumor edge to subventricular zone and idh mutation predicts prognosis of patients with glioma |
| topic | glioma MRI subventricular zone isocitrate dehydrogenase 1 prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.693693/full |
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