Modafinil decreases anxiety-like behaviour in zebrafish
Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2017-02-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/2994.pdf |
| _version_ | 1797425653110276096 |
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| author | Adrian Johnson Trevor James Hamilton |
| author_facet | Adrian Johnson Trevor James Hamilton |
| author_sort | Adrian Johnson |
| collection | DOAJ |
| description | Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we administered doses of 0, 2, 20, and 200 mg/L for 30 minutes then tested zebrafish in the novel approach test. In this test, the fish was placed into a circular arena with a novel object in the center and motion-tracking software was used to quantify the time the fish spent in the outer area of the arena (thigmotaxis zone), middle third of the arena (transition zone) and center of the arena, as well as total distance traveled, immobility and meandering. Modafinil caused a decrease in time spent in the thigmotaxis zone and increased time spent in the transition zone across all doses. Modafinil did not significantly alter the time spent in the center zone (near the novel object), the distance moved, meandering, or the duration of time spent immobile. We also validated this test as a measure of anxiety with the administration of ethanol (1%) which decreased time spent in the thigmotaxis zone and increased time spent in the transition zone. These results suggest that modafinil decreases anxiety-like behaviour in zebrafish. |
| first_indexed | 2024-03-09T08:19:11Z |
| format | Article |
| id | doaj.art-05598844e5394d1a8413d3239f3b4f84 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:19:11Z |
| publishDate | 2017-02-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-05598844e5394d1a8413d3239f3b4f842023-12-02T21:53:32ZengPeerJ Inc.PeerJ2167-83592017-02-015e299410.7717/peerj.2994Modafinil decreases anxiety-like behaviour in zebrafishAdrian Johnson0Trevor James Hamilton1Department of Psychology, MacEwan University, Edmonton, Alberta, CanadaDepartment of Psychology, MacEwan University, Edmonton, Alberta, CanadaModafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we administered doses of 0, 2, 20, and 200 mg/L for 30 minutes then tested zebrafish in the novel approach test. In this test, the fish was placed into a circular arena with a novel object in the center and motion-tracking software was used to quantify the time the fish spent in the outer area of the arena (thigmotaxis zone), middle third of the arena (transition zone) and center of the arena, as well as total distance traveled, immobility and meandering. Modafinil caused a decrease in time spent in the thigmotaxis zone and increased time spent in the transition zone across all doses. Modafinil did not significantly alter the time spent in the center zone (near the novel object), the distance moved, meandering, or the duration of time spent immobile. We also validated this test as a measure of anxiety with the administration of ethanol (1%) which decreased time spent in the thigmotaxis zone and increased time spent in the transition zone. These results suggest that modafinil decreases anxiety-like behaviour in zebrafish.https://peerj.com/articles/2994.pdfZebrafishModafinilAnxietyLocomotor activityNovel approach testEthanol |
| spellingShingle | Adrian Johnson Trevor James Hamilton Modafinil decreases anxiety-like behaviour in zebrafish PeerJ Zebrafish Modafinil Anxiety Locomotor activity Novel approach test Ethanol |
| title | Modafinil decreases anxiety-like behaviour in zebrafish |
| title_full | Modafinil decreases anxiety-like behaviour in zebrafish |
| title_fullStr | Modafinil decreases anxiety-like behaviour in zebrafish |
| title_full_unstemmed | Modafinil decreases anxiety-like behaviour in zebrafish |
| title_short | Modafinil decreases anxiety-like behaviour in zebrafish |
| title_sort | modafinil decreases anxiety like behaviour in zebrafish |
| topic | Zebrafish Modafinil Anxiety Locomotor activity Novel approach test Ethanol |
| url | https://peerj.com/articles/2994.pdf |
| work_keys_str_mv | AT adrianjohnson modafinildecreasesanxietylikebehaviourinzebrafish AT trevorjameshamilton modafinildecreasesanxietylikebehaviourinzebrafish |